Cold Sores: Causes and Treatment


It is quite uncomfortable and embarrassing, you go down the street, meet someone, and to see his face, his gaze is directed immediately to your lips, and of course, it is not normal to see someone with outbreaks It is quite uncomfortable and embarrassing, you go down the street, meet someone, and when I saw you in the face, immediately his gaze directed toward your lips, and of course, it is not normal to see someone with outbreaks in that part or any another face; this is some of the reactions people have when they see someone who is suffering from cold sores, and it is not pleasant to have it. Cold sores are a fairly common disease and annoying. And to make matters worse it is for many is an annoying companion of life because if not treated properly, buds disappear, but not soon appear again. This is because for sure the virus stays in the body; remain latently but “concealed” in those who suffer until reactivated recurrently with small and large blisters sometimes popularly known as fires. Fever is one of the triggers when reactivated the virus, but not the only one. , Sudden changes in temperature, solar radiation or small lesions on the lips are also great influential in this case. When this happens, the virus is transported to the sensory axons and when it reaches the target area, instantly infects epithelial cells and causes a new infection that awakens the monster that haunts you: cold sores. Are there treatments for cold sores? It can relieve pain that this type of herpes because if you avoid eating spicy or acidic foods, ice application, among others. Now, if you looking for medicines containing anesthetic agents such as phenol and menthol in order to reduce cracking and / or soften the crusts. There are also remedies used to help accelerate the momentary “healing” and reduce pain as possible. But these should be used several times a day to achieve the desired objective and is trying to eliminate herpes.

But time and many tests have shown that these drugs fail much about the healing of cold sores. It is quite uncomfortable and embarrassing, you go down the street, and immediately his gaze directed toward your lips, and of course, it is not normal to see someone with outbreaks Doctors may recommend an anesthetic gel to relieve pain or an oral antiviral drug to speed up the process. The most common antiviral drugs used in these cases are: Acyclovir (Zovirax), famciclovir (Famvir) and valacyclovir (Valtrex) but it turns out that these 1. are usually expensive, and 2. not going to permanently cure because when you least think, l cold sores be visiting again. Cold sores can become complicated if you get a bacterial infection, so it is also important that you keep the lips clean by washing thoroughly with soap and water, according to the seriousness of the case. But when we look at natural medicine, and give you an opportunity to this, the benefits may be surprised, in fact, that was in my case, I was desperate, and I thought q no longer had anything to do with the type of herpes I had, until one day, in my desperate search for a definitive solution herpes my problem, I found http://curesuherpes. com/ there, I could hear that was not the only one with this problem, and thanks this guaranteed treatment that provides Jorge Amell in his book “they Eliminate Herpes quickly and efficiently” are already a lot of people with their testimonies assure us that it is a natural, modern, and very effective treatment. Thanks to http://curesuherpes. com/ I am now more, I join the list of people 100% cured of herpes, treatment of Jorge Amell is used for different types of herpes, so go and check it out your page, I am quite sure you will not regret it.

Millennium Institute for Immunology and Immunotherapy develops herpes simplex virus vaccine

BioNoticias / InvestigaciónJueves, April 16, 2015 Dr. Pablo Gonzalez, Assistant Professor of the Catholic University and Young Investigator Millennium Immunology and Immunotherapy, IIHI Institute, together with a team of scientists from the US, are protagonists of a global milestone for science: develop an effective vaccine herpes simplex virus 1 and 2. The vaccine aims to prevent the harmful effects of these viruses, after infecting, can lead to blindness, neonatal and adult encephalitis, and skin lesions, also remained chronically in the body, with the possibility to reactivate sporadically throughout life the individual. Vaccine Prophylactic formulation is being developed and tested in animal models and Pablo González explains Doctor in Genetics and Molecular microbilogy, “the results are amazing. ” “The strategy we have used to create this vaccine caused surprise among our colleagues, experts in the field, as we use completely opposite to that used by major multinational pharmaceutical companies working on a vaccine against these viruses, for two decades approximation” . The researcher explains that while these recognized laboratories have invested efforts to this end, “the results obtained in different clinical phases have been disappointing. Hardest hit was two years ago in a phase 3 clinical proved fruitless. ” On the other hand, Dr. Gonzalez points out that currently there is no vaccine against herpes simplex, and that current drug treatments, such as Acyclovir, are not very effective “as they generally only manage to shorten the duration of the disease in a few days and do not remove the body of the virus. ” For this reason, the researcher says it is essential that health services can have preventive vaccines, to avoid from the outset the clinical manifestations caused by these pathogens.


opposite strategy “Labs interested in creating vaccine against herpes simplex virus have focused primarily on a single viral protein called gD. Our studies, however, is focused on all the viral proteins, less gD. To do this we create an attenuated strain of the virus lacking this protein, which has been the focus of many. The results of our study showed that the attenuated strain is able to confer immune exceptional protection against infection, functioning as an ideal vaccine, “explains the scientist. This novel and contrary to trends to date, strategy is a paradigm shift, according to Dr. Gonzalez. In fact, the study led proposes that gD not be necessary to create a protective immune response, but rather it could have a negative effect on the immune system “approach that also arises from other recent scientific papers on the topic” says the researcher. The new vaccine consists of an attenuated mutant virus, which is trapped in the cells, unable to go out and continue to infect other neighboring cells. Being content, functions as a “suicide virus” which reveals its entirety the immune system unable to replicate or cause disease. “We believe this vaccine property provides the immune system of all components of the virus that are associated with natural infection, allowing us to create a powerful antiviral immune response prior to the encounter with infectious virus. Vaccination works essentially as a mock infection very effective, “says the scientist. The laboratory of Dr.

Pablo Gonzalez, located on the PUC, and also composed of PhD students and undergraduate thesis students, focuses on identifying and characterizing viral elements that make these microbes are harmful. In this context, the work done there to “determine what viral elements trick the immune system, will allow us to eliminate the virion to design better vaccines against herpes simplex virus”. silent virus Herpes simplex, like other herpes viruses such as varicella zoster, has unusual features, including being able to stay in our cells for life, staying there silently, dormant. Herpes simplex virus type 1, affects on average 70% of the population, while the type 2 to 20%. However, clinical manifestations occur only between 5% and 15% of people. In other words, most of those infected do not know it. In particular, herpes simplex 1 and 2 are the leading cause of viral encephalitis, a problem that leaves important consequences, especially in newborns. On the other hand, HSV-1 is the leading cause of blindness in developed countries. The place of refuge for these viruses in the body’s nerve tissue, specifically in neurons, because there they are protected from the immune system. However, when it is threatened, the virus escapes from these cells and appears near the initial site of infection in skin and mucous membranes creating new infections in the individual. “This can happen, for example, to excessive exposure to UV rays, allergens or when food is consumed when people have low in their defenses, among other factors,” says the researcher PUC-IIHI. For this reason, he adds, it is essential to know the mechanisms by which these viruses operate and, on that basis, to advance the field of biomedical research for the treatment and prevention of diseases caused by these viruses.

By: Agnes Llambías Communications Agency.

You know the symptoms of ocular herpes?


Ocular herpes is a common infection of the eye, mainly driven by the herpes simplex virus. Although a single episode of herpes eye tends to resolve without complications, in some cases, the infection can cause scarring on the cornea or, worse, compromise irreversibly view. For this reason, any suspected ocular herpes requires immediate diagnostic evaluation to be performed as soon as a specific treatment to combat the virus. Causes and transmission mode Ocular herpes is caused mainly by a supported by the herpes simplex virus type 1. The virus can be transmitted by more than one method infection: – Through contact with a person suffering from cold sores, eye or, less often, genitals. – Self-contamination: the spread of the virus can occur simply touching your eyes with your hands after having scratched or rubbed herpetic lesion (eg, lips. ) Reactivation of the virus Ocular herpes, unfortunately, it tends to recur more often in the same patient. As we know, once the infection contracted, herpes viruses tend to hide along the nerve endings: here, they can remain silent for life – so they do not cause any symptoms – or episodes are repeated at certain times. In 40-50% of cases, patients affected by ocular herpes again manifest the same symptoms of infection.

Types of ocular herpes Depending on the depth of the infection in the eye, they stand out more forms of ocular herpes: -The Herpetic keratitis: Corneal infection is probably the most widespread type, which affects the surface layer of the cornea. Typically, this type of infection in the eye heals without scarring on the cornea. Stromal -Queratitis: sustained infection with herpes simplex can be deeper reaching the stroma (the middle layer of the membrane of the cornea). This infection is very dangerous when not treated in time, in fact, can cause scarring of the cornea, therefore, a progressive deterioration of vision leading to blindness. -Iridociclitis: Sustained ocular herpes simplex infection when it reaches the ciliary body and iris. Such internal ocular structures become inflamed, which degenerates in sensitivity to light (photophobia), blurred vision, eye pain and redness of the eyes. Iridocyclitis is a specific type of viral uveitis. -Retinitis: When the infection affects the retina or the innermost layer of the eye, ocular herpes takes the name of herpetic retinitis.

Chilean magazine of infectious diseases – herpetic eczema herpes simplex virus type 2: Review of

Rev Chil Infect 2009; 26 (4): 356-359 CLINICAL CASE herpetic eczema herpes simplex virus type 2. Review of the literature apropos of a case Eczema Caused by herpes simplex herpeticum virus type 2. Review of the literature About one case Francisca H. Schroeder, Andrea Elgueta N. and M. José Martínez G. Barros Luco-Trudeau Hospital, Santiago, Chile Service of Dermatology and Venereology (FSH, AEN) University of Chile, Santiago School of Medicine ICBM-Virology Program (MJMG) Correspondence to:

Eczema is an EXTENSIVE herpeticum vesicular eruption Caused by cutaneous dissemination of herpes simplex virus in Patients Who Have underlying skin conditions or epidermal barrier disruption. Herpes simplex virus type 1 (HSV 1) The most common etiology is. This is the first report in Chile of a case of eczema herpeticum Caused by HSV 2 in a patient With Darier ‘s disease, We review the literature and Emphasize the use of sensitive and specific Assays Real as time Polymerase Chain Reaction, That allow to initiate Timely the correct treatment. Key words: Eczema herpeticum, Kaposi varicelliform eruption, herpes simplex virus type 2. Summary Herpetic vesicular rash Eczema is a skin caused by extensive spread of herpes simplex virus in patients with previous skin disorders or damage to the epidermal barrier. The most common cause is herpes simplex virus type 1 (HSV 1), although there have been cases of herpes simplex virus type 2 (HSV 2). We present the first report in Chile eczema herpetic HSV 2 in a patient with Darier disease. We review the literature and emphasize the importance of using sensitive and specific as the polymerase chain reaction (RPC) in real time, which allow early initiation of appropriate therapeutic techniques. Keywords: Herpetic eczema, rash varicelliform sarcoma, herpes simplex virus type 2. Introduction Eczema is herpetic cutaneous dissemination of herpes simplex virus in patients with chronic skin diseases, especially atopic dermatitis. It also occurs in patients with other chronic skin diseases (Darier’s disease, pityriasis rubra pilaris, psoriasis and other less frequent), or who have damage to the epidermal barrier.

Most of the cases described in the literature are caused by HSV 1 2-6 and there are only a few reported cases of eczema herpetic HSV 27,8. We present the first report of herpetic eczema HSV 2 in our country. Clinical case 45 year old man, previously healthy, derived from the ES to the Dermatology Department of Hospital Barros Luco Trudeau, by a picture of two weeks of evolution, characterized by acute and progressive appearance of skin lesions on the trunk. In the clinical history only he highlighted the history of a recurrent eruption of the trunk from 18 years of age, characterized by asymptomatic erythematous papules in the sternum region and arms. No history of herpes infections of the skin or genitals, skin diseases or family. Physical examination was in good general, afebrile condition and had multiple papules and pustules on the trunk umbilication, confluent, with some lesions scab stage (Figures 1 and 2). No injuries to the face, genitals and mucous membranes. In the hands he revealed the presence of skin-colored papules flattened on the back, palmar pits and alternating red and white lines on the nails, findings suggestive of Darier disease (Figure 3). He was hospitalized with a presumptive diagnosis of herpetic eczema and Darier’s disease. general examinations, current culture and polymerase chain reaction (RPC) for herpes simplex virus pustules, and biopsy of skin lesions suggestive of Darier’s disease were performed. Empirically treatment with oral acyclovir indicated 400 mg 5 times a day and ev cloxacillin 1 g every 6 hrs, which was maintained for 10 days. Among the general tests normal blood count, VHS 29 mm / h, CRP 123 mg / L, GGT 108 U / L was found.

The results of the VDRL and serology for HIV and HBV were negative. The skin culture was positive for methicillin-resistant Staphylococcus aureus only clindamycin and erythromycin, and real-time PCR, conducted at the Laboratory of Virology of the Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, was positive for HSV 2 . histopathologic findings of skin biopsy were consistent with Darier disease. The patient responded quickly to treatment, he was discharged after 10 days. Discussion Patients with chronic skin diseases, especially atopic dermatitis carriers are at increased risk of developing a skin spread of certain viruses such as herpes simplex virus, Coxsackie virus and the virus Alo vaccinia1,9,10. This clinical picture is known as Kaposi chicken pox rash. The most common cause of Kaposi varicelliform eruption, is the spread of herpes simplex virus in atopic patients, which has been called more specifically herpetic eczema. However, the term herpetic eczema also used for cutaneous dissemination of herpes simplex virus in patients with other chronic skin diseases (Darier’s disease, cutaneous T-cell lymphoma, pityriasis rubra pilaris, benign familial pemphigus, erythroderma congenital ichthyosiform dermatitis seborrheic, Wiskott-Aldrich syndrome, psoriasis, lupus erythematosus) or having epidermal barrier damage (contact dermatitis, burns, grafts, dermabrasion). Similarly, the spread of vaccinia virus in atopic patients (or carriers of other dermatoses) vaccinatum1 known as eczema. Currently, vaccination against smallpox (eradicated disease in the world at the end of the 1970s) is indicated only in emergency situations (Outbreak) and laboratory personnel or health workers who are at risk of acquiring the vaccinia virus or related viruses. Because eczema vaccinatum is a serious complication of this vaccine, the CDC of Atlanta believes that the personal history of atopic dermatitis is a contraindication to vacunación1,11,12. Have been proposed various immuno-logical mechanisms to explain eczema herpeticum in atopic patients: impaired immunity against herpes simplex virus mediated by T cells, a defect in the specific antibodies to the virus, a decrease in NK cells and receptors IL-2, an inhibition of Th-1 response by increased IL-4, decreased cathelicidins (a family of antimicrobial peptides that are part of the innate immunity) or a decrease in producing plasmacytoid dendritic cells interferon I1,13 type.

Another possibility is simply viral spread is facilitated by the disruption of the skin barrier that exists in both atopic dermatitis and other skin conditions associated with eczema herpético1. A retrospective clinical study of 100 cases of herpetic eczema showed as only risk factors, early age of onset of atopic dermatitis and high total IgE levels in atopic and ruled out the use of topical corti-costeroides as predisponente14 factor. Some case reports and prospective studies have found an association between the use of topical calcineurin inhibitors in atopic patients and the development of eczema herpético15-19. Herpetic eczema may result from a primary infection or a recurrence of herpes simplex virus. Most reported cases have been caused by HSV 1 2-6 and only found two cases published by 27,8 VHS. Coincidentally both cases HSV 2 occurred in patients with Darier’s disease, a rare disorder of keratinization, autosomal dominant inheritance with variable penetrance, characterized by hyperkeratotic papules in seborrheic areas, manifested at puberty, with exacerbations and remissions along the life3. The primary form of herpetic eczema (or first episode) is characterized by a monomorphic rash consisting of vesicles that progress to vesicular-pustules umbilication and may coalesce forming crusted plates with varying degrees of bleeding, disease characteristics. Lesions first appear on the skin damaged by the underlying pathology and gradually spread in 7 to 10 days, accompanied by fever, chills skin and lymph nodes. There are also localized forms, without extensive dissemination. The average disease duration is 16 days (range 2 to 6 weeks) 1. 13. Between 13 and 16% of patients may develop recurrent episodes of eczema herpético14. In these cases, the clinical picture is more limited, less commitment general1,13 state.

The most common complication of these patients is bacterial-infection of the lesions, S. aureus being isolated more frecuencia20 agent. More serious complications are secondary viremia with involvement of other organs, bacterial sepsis or ocular herpes simplex virus infection. Despite the high frequency of facial injuries, herpetic keratitis is rare, even in patients who have isolated virus conjuntival1,13 mucosa. The clinical diagnosis of eczema herpeticum should be suspected in the presence of distinctive lesions in a patient with impaired skin barrier base, especially atopic dermatitis. The main differential diagnoses are VZV infection, impetigo and contact dermatitis. The presence and type of herpes simplex virus involved may be confirmed by viral, immunofluorescence or RPC torula a specimen obtained vesicle floor insulation. If this is not possible, the presence of giant cells in the test Tzanck can guide the diagnosis of herpes infection; its sensitivity can reach 70% depending on the state of the injury, it is a rapid, inexpensive method which allows early initiation of antiviral treatment. Skin biopsy shows characteristic histological changes of herpetic infection (epidermis with intra- and intercellular edema, intranuclear inclusion bodies eosinofilíeos and multinucleated giant cells). If a bacterial super-infection of lesions suspect a corriente1,13 culture should be performed. The mainstay of treatment of herpetic eczema is active nucleoside analogues against herpes simplex virus, such as acyclovir or valaciclovir, which has decreased the lethality of this disease from 50% to less than 10% 13. There is a controlled, multicenter, double-blind, randomized clinical trial comparing 200 mg 5 times daily oral acyclovir for 5 days versus placebo in 60 immunocompetent patients. This study showed that acyclovir therapy in these doses accelerates clinical recovery of patients and reduces the duration of ulcers, with all patients without lesions on the tenth day of starting treatment.

a significant difference in duration of viral excretion groups8 between the two was not found. However, since the herpetic eczema is a serious pathology is recommended valacyclovir (1 g every 8 hours for 7 to 10 days, depending on patient outcomes), due to their greater biodisponibilidad1. It should be noted also that acyclovir could be used ev, according to the severity of the patient. References 1. Kramer S, Tilomas C, Tyler W, Elston D. Kaposi’s varicelliform eruption: A case report and review of the literature. Cutis 2004; 73: 115-22. [Links] 2. Pantazi V, Potouridou I, Katsarou A. Papadogiorgaki H, Katsambas A. Darier’s disease complicated by Kaposi’s varicelliform eruption due to herpes simplex virus.


J Eur Acad Dermatol Venereol 2000; 14: 209-11. [Links] 3. Roustan G, F Goalkeeper Martin P. acute vesicular rash on the trunk. 2002 Clin Infect Dis; 20: 533-4. [Links] 4. Saraswat A, Ratho K, Kumar B. Two unusual cases of Kaposi’s varicelliform eruption. Acta Derm Venereol 2002; 82: 138-9. [Links] 5.

Kosann M K, J Fogelman P, R L. Stern Kaposi’s varicelliform eruption in a patient With Grover’s disease. J Am Acad Dermatol 2003; 49: 914-5. [Links] 6. Umene K, Yoshida M, Sakaoka H. Comparison of the association with eczema herpeticum in the two predominant genotypes of herpes simplex virus type 1. J Med Virol 1996; 49: 329-32. [Links] 7. Hazen P G, R B. Eppes herpeticum Eczema Caused by herpesvirus type 2. A case in a patient With Darier disease.

Arch Dermatol 1977; 113: 1085-6. [Links] 8. Niimura M, Nishikawa T. Treatment of eczema herpeticum With oral acyclovir. Am J Med 1988; 85 (2A): 49-52. [Links] 9. Monckton Copeman P-W, H Wallace J. Eczema vaccinatum. Br Med J 1964; 2: 906-8. [Links] 10.

Salo O P, M J. Valle Eczema vaccinatum in a family with Darier’s disease. Br J Dermatol 1973; 89: 417-22. [Links] 11. Engler R J, Kenner J, Leung D Y. Smallpox vaccination: Risk considerations for Patients With atopic dermatitis. J Clin Immunol 2002 Allergy; 110: 357-65. [Links] 12. Cono J, Casey C G, Bell D M; Centers for Disease Control and Prevention. Smallpox vaccination and adverse reactions. Guidance for Clinicians.

MMWR Recomm Rep 2003; 52 (RR-4): 1-28. [Links] 13. K. McKenna J Kaposi varicelliform eruption. www. emedicine. com/derm/topic204. htm (accessed 17 September 2008). [Links] 14. Wollenberg A, Zoch C, Wetzel S, G Przybilla Plewig B. Predisposing factors and clinical features of eczema herpeticum: a retrospective analysis of 100 cases.

J Am Acad Dermatol 2003; 49: 198-205. [Links] 15. – Lübbe J, Pournaras C C, J H. Saurat herpeticum Eczema atopic dermatitis During treatment of 0. 1% tacrolimus ointment With. Dermatology 2000; 201: 249-51. [Links] 16. Miyake M-Kashima, K. Tanaka M Fukagawa, Takano Y, Dogru M, Asano-Kato N. et al. Kaposi varicelliform 0.

1% eruption Associated With tacrolimus ointment in atopic blepharitis treatment. Cornea 2004; 23: 190-3. [Links] 17. Papp K A, Werfel T, Fölster-Holst R; Ortonne J P, P C Potter, Prost Y, et al. Long-term monitoring of atopic dermatitis pimecrolimus cream 1% With infants and young children in: a two-year study. J Am Acad Dermatol 2005; 52: 240-6. [Links] 18. – Paul C, M Cork, Rossi A B, Papp K A, Barbier N, Y. Prost Safety and tolerability of 1% pimecrolimus cream Among infants: Experience with 1,133 Patients Treated for up to 2 years. Pediatrics 2006; 117: ell8-28. Epub 2005 Dec 15.

[Links] 19. Osawa K, Etoh T, Ariyoshi N, Ishii I, Ohtani M; Kariya S, et al. Relationship Between Kaposi’s varicelliform eruption in Japanese Patients With atopic dermatitis Treated With tacrolimus ointment and genetic polymorphisms in the IL-18 gene promoter region. J Dermatol 2007; 34: 531-6. [Links] 20. – Brook I, Frazier E H, J Yeager K. Microbiology of infected eczema herpeticum. J Am Acad Dermatol 1998; 38: 627-9. Rev Chil Infect 2009; 26 (4): 356-359 [Links] Received: March 28, 2008 Accepted: January 20, 2009 Correspondence to:

 Francisca Schroder Hanke lulateno@hotmail. com

The cause of MS

The cause of Mexican scientists esclerosisLos Julio Sotelo and Adolfo Martinez say they have discovered that the common varicella virus causes most cases of multiple sclerosis, in an interview published today by the newspaper Reforma. Sotelo, neurologist, and Martinez, microbiologist, found that 95% of patients with severe multiple sclerosis analyzed had chickenpox in childhood. In addition, they showed that this virus behaves the same ‘intermittency’ that sclerosis, a chronic degenerative disease that attacks the nervous system, but experience periods of remission, where the disease enters a recess and symptoms can be ameliorated. Multiple sclerosis affects the nervous system that affects vision, causes muscle weakness, problems with coordination and balance, memory corruption, and in the most severe cases disability. The two researchers have just published an article in the journal Annals of Neurology, one of the most prestigious in the field, which details his findings, highlights the newspaper. For their study they analyzed 19 patients with stage disease exacerbated, who extracted cerebrospinal fluid. Thus, they could verify the simultaneous presence of active varicella virus (known as varicella-zoster) in the group of patients with multiple sclerosis, a disease that produces scars in the brain that prevent the production of myelin, a protein that surrounds nerve fibers and facilitates the transmission of nerve impulses. ‘We extracted and identified cerebrospinal fluid (varicella virus) in the brain of each of the patients we studied. This was our check ‘Martinez said, according to the newspaper version. To date the origin of MS is unknown and has not developed a cure. The accepted theory was the date that is an autoimmune disease, consisting the patient’s immune system attacks the body parts and organs instead of protecting. Martinez, for whom the discovery is ‘greatest achievement’ of his academic career, chairs the Advisory Council of Sciences and the Bioethics Committee of Unesco, and is a researcher at the Center for Research and Advanced Studies (CINVESTAV) Polytechnic Institute Nacional (IPN), one of the most important scientific centers in Mexico. In his view, ‘now we have to improve the varicella vaccine and rethink drugs’ to treat it.

Sotelo is a researcher at the National Institute of Neurology and Neurosurgery Manuel Velasco Suarez, and its scientific achievements account have devised a treatment for detecting cerebral cysticercosis. Terra Actualidad – EFE Source: http://actualidad. terra. es/ciencia/articulo/cientificos_mexicanos_descubren_virus_podria_2373798. htm Zoster virus Varicella-in cerebrospinal fluid at relapses of multiple sclerosis Julio Sotelo, MD1 *, Adolfo Martinez-Palomo, MD, dsc2, Graciela Ordoñez, MSC1, Benjamin Pineda, PhD1 1Neuroimmunology Unit, National Institute of Neurology and Neurosurgery, Center for Research and Advanced Studies, Mexico City, Mexico 2Department of Experimental Pathology, Center for Research and Advanced Studies, Mexico City, Mexico Email: Julio Sotelo (jsotelo@servidor. unam. mx)


Objective Recent studies in peripheral blood mononuclear cells (PBMCs) Have Indicated That exacerbations of multiple sclerosis (MS) Could Be Associated With the reactivation of latent varicella-zoster virus (VZV). Methods Ultrastructural observations for viral particles Were made by electron microscopy in cerebrospinal fluid (CSF) from 15 MS Patients During relapse, 19 MS Patients During remission, and 28 subjects control. Initial findings Were reproduced in a cohort confirmation. In Addition, from VZV DNA was Quantified by Real-time polymerase chain reaction in CSF and PBMCs from a large number of MS Patients (n = 78). results We found by electron microscopy the presence of abundant viral particles identical to VZV in CSF from MS Patients Obtained Within the first few days of an acute relapse. In contrast, viral particles Were not seen in CSF samples from MS Patients in remission or subjects from neurological control. Also, DNA from VZV was present in CSF and in PBMCs During relapse, disappearing in MOST Patients During remission. The mean viral load was 542 times greater than in CSF at relapse and remission in CSF at 328 times greater in CSF at relapse than in PBMCs at relapse. Interpretation The ultrastructural finding of viral identical particles to VZV, Together with the simultaneous presence of large quantities of DNA from VZV in the subarachnoid space, almost restricted to the periods of exacerbation, as well as ITS steady diminution and eventual disappearance from clinical relapse to clinical remission Constitute are surprising and the strongest evidence to support the participation of VZV in the pathogenesis of MS.

Ann Neurol 2008 Received: 3 August 2007; Revised: 30 October 2007; Accepted 5 November 2007 Digital Object Identifier (DOI) 10. 1002 / ana. 21316 Source: http://www3. interscience. wiley. com/cgi-bin/abstract/117922937/ABSTRACT Mexican scientists discovered a strong link between the virus and the most severe form of the disease – detect the pathogen in the brain fluid of advanced sick The key cause of juvenile disability might be in a common ailment, varicella-zoster Scientists have spent decades MADRID.

– searching for the source of a disease, multiple sclerosis, which stands as the leading cause of disability among young people and affects only in Spain, more than 20,000 people. Since suspected might behind this mysterious and dramatic disease, degenerative and intermittent character, he is some kind of pathogen, probably a virus. However, the most accepted theory among the medical community says that it is an autoimmune disease, ie, they are the patient’s defenses provoke it to attack the tissues. double manifestation Now, Mexican scientists from the National Institute of Neurology and Neurosurgery claim to have found the key: the chicken pox virus, one of eight known infectious herpes could be the cause of the disease. Chickenpox, a common childhood disease that can manifest itself again in adulthood through the shingles, is a virus that remains dormant in nerve tissue throughout life. Sclerosis appears irregular and differentiated in each patient, who often suffer outbreaks or intermittent relapses, which, depending on the severity, can cause irreversible damage. It is diagnosed as young as age 20, and can even leave the sick in a wheelchair over a period of seven to twenty years. According to the journal “Annals of Neurology”, the researchers found the presence of the pathogen in patients with the severe form of the disease in the outbreak, when your nervous system stopped producing myelin, a substance essential for the transmission of nerve signals, It is causing healing scabs or plates in different parts of the nervous system, hence the multiple. “We extracted the cerebrospinal fluid and identify the varicella virus in the brains of all patients studied” (twenty) ensure the neuroinvestigadores Julio Sotelo and Adolfo Martinez Palomo, the study authors. “There were the virus, but no one had seen or had happened seek them in this liquid,” explains Martinez Palomo in an interview with the Mexican newspaper “Reforma”. Scientists hope their findings allow to curb multiple sclerosis, whose incidence is growing in the developed world and which already affects around 400,000 people in the US. The disease affects the central nervous system, causing conditions in vision, muscle weakness, impaired coordination and balance, memory corruption, and the most severe disability cases.

And all right in the prime of life of patients, which makes it more traumatic if possible. “I do not know well the origin of the inflammatory process that leads to suffer the crisis, but already suspected that behind could have a previous viral infection; in fact, there are lines of research in this regard with other viruses, “says José Miguel meanwhile Lainez, head of Neurology at the Clinical Hospital of Valencia. “The discovery is important, but the sample is very small, so we have to deepen their study. ” What impact would the finding confirmed its veracity? “It would have to work, first, in preventing outbreaks and then a healing therapy, because existing are only palliatives,” explains neurologist. Source: http://www. larazon. es/32576/noticia/Sociedad/La_varicela,_responsable_de_la_esclerosis

A vaccine prevents shingles and neuralgia> elmundo.es health

LIKE A CHILD A vaccine prevents shingles and neuralgia JAVIER MARCO BESIDES . . . Shingles and its most feared complication, postherpetic neuralgia, could suffer a serious setback in the coming years. A new and more potent vaccine against varicella-zoster virus (the causative agent of this disease) has shown dramatic effectiveness in adults over 60 years as remarkably reduces the chances of suffering and its severity when it occurs. Chickenpox, a disease that usually appears in childhood, is caused by the varicella-zoster virus (VZV). After infecting the child, this microorganism takes refuge in the sensory nerve ganglia and can stay asleep the rest of life. However, it can be reactivated in a given adulthood and travel through nerve roots to the skin, where it produces a new painful rash with blistering or blistering time: it is what is called shingles. A more potent vaccine There is an effective childhood vaccine to prevent childhood chickenpox with which there has been some controversy over its inclusion in the compulsory immunization schedule.


Based on this product, a US group focused on research on the prevention of shingles has tested a new vaccine in adults. The study in question uses a reinforced childhood vaccine (Oka / Merck VZV) in order to demonstrate whether administration to over 60 years is able to reduce both the cases of herpes zoster and postherpetic neuralgia and its severity version. Shingles occurs mainly in older subjects because their immunity is less effective. In addition to the intense discomfort that often accompany skin lesions, this infection leaves quite often a residual pain, sometimes intense. It is called post-herpetic neuralgia. Other rarer but more serious complications of this infection are the involvement of the spinal cord or even the nervous system infection and inflammation of the vessels, which can leave serious sequelae such as urinary incontinence, loss of mental functions, paralysis of any area of ​​the body and other serious disorders. The results In this research, published today in The New England Journal of Medicine, 38546 subjects who randomly received half a dose of placebo or vaccine were recruited. During follow-up (over three years), they evaluated the cases of herpes in both groups as well as the duration and intensity of pain. neuralgia cases were also analyzed. The results have been spectacular as in vaccinated adults herpes cases were reduced by 51% and neuralgia by 66%. Moreover, pain and discomfort were clearly less intense (61%) occurred when the disease in patients immunized with the new compound. the hypothesis that VZV reappears in adults as decrease their defensive capabilities, something that occurs naturally with age is fulfilled.

The new vaccine achieved in this case, revive or refresh the memory of immunity against the virus so that it manages to prevent its occurrence or at least reduce its activity. The vaccine stimulates the immune system to prevent the virus reactivates, but is not expected to help treat people who already have shingles. The problem is not small as it is estimated that more than 36% of patients aged 60 years and above 47% of those over 70 suffer severe pain even a year after having the Shingles. And besides, there is no effective remedy adequately control these symptoms. In fact, it is estimated that the suffering of one of these patients is equivalent to that someone can suffer heart failure, myocardial infarction, diabetes or severe depression. Start vaccinating and The editorial accompanying this study, also published in ‘New England’ logically arises whether the time has come to recommend this new vaccine to any healthy middle-aged adult. It is likely that in the future there are many cases of shingles, as currently stated, as they reach adulthood children are now being vaccinated against chickenpox. Second, and more importantly, any health measure applied to large masses of people should stand the test of profitability. It is estimated that each year of life gained quality of the vaccine costs about € 1,800 or even less if the benefit extends beyond the three years the study lasted. This figure is more than enough to consider the cost-effective vaccine (the theoretical limit of this type of sanitary measures is around 39,000 €). For the author of the editorial, it is even possible that this vaccine could get to save money by preventing a large number of cases. At the moment, your recommendation is to start using it without waiting the 10 years that would make the long clinical trials require official agencies for marketing.

Of course, keeping a close eye vaccinated, especially those over 85, in which the answer may not be as effective. This way you get better understanding of the capabilities of this immunization and their risks in the elderly population that after all is the most affected by the problem. In fact, according to The New York Times, the manufacturer of the vaccine (Merck Sharp \x26amp; Dohme) has already asked the US Food and Drug Administration (FDA) approval of this vaccine, you expect to receive in February. It would be the first vaccine for older adults in 30 years, according to the company.

Dry eye (I): Concept and causes – Ocularis

After these latest entries, say, non-scientific, I return with desire to speak of an eye. I have to say that this series of articles beginning make me illusion; I will talk about the most common disease of ophthalmology (excepting refractive errors): dry eye. Virtually everyone has, has had or will have dry eye at some point. Importance Well, what I said before: leaving aside the issue of graduation, is the most common eye problem. In addition, given our conditions and lifestyle, the prevalence of the disease increases. On the other hand, rarely curative treatment, so a person with dry eye, dry bearing will follow. It can be associated with other diseases or conditions, such as intolerance to contact lenses, blepharitis (chronic inflammation of the edge of the eyelids, usually associated with an oily secretion altered at that level), the use of computers, etc. It produces symptoms that can be quite annoying, and treatment, though effective, is often not satisfactory for the patient and not well met. A bit like happens with floaters, patients “expect more” ophthalmologist, want a more definitive solution to their symptoms. Definition Perhaps the name “dry eye” leads to a misconception. Not exactly that teardrop missing, at least not always.

In fact, one of the symptoms of dry eye is, ¡el tearing ! . We will choose one definition more close to reality, and then we will discover what it means. We mean by dry eye that situation in which the tear film remains stable not. To understand what we mean, we must talk about the ocular surface (talk about it in the article of the lenses). Ocular surface consists of three structures: – Cornea: The transparent structure that is in the anterior part of the eye more. It is almost always “invisible” see-through iris. It is most noble part of the eye surface. The main objective is that the cornea is always wet. – Conjunctivitis: HATH above the white of the eye, is a translucent “skin” with blood vessels. It also has to be constantly moist, but not as sensitive as the cornea dryness. – Moive tear: The protagonist of the article.

It is continuously produced by some glands (there is one that is larger than in the drawing shown above and to the left, and many that are microscópicas), and goes eliminating the lacrimal tract blockage, a “little tubes” next to the bridge nose, carrying the teardrop to the nostril (and drawing are on the right side). The tear film has a special compositing, I describe now. Composition of the teardrop The tear film consists of water in more than 90%, but has other components that are critical to remain stable. ¿Y why water can not be all ? . Because water does not have a suitable surface tension. As this blog is not physical, rather than explain what is the surface tension, I’ll give an example: sure we’ve all played when we lavábamos hands of small ± or to make “soap rings”. With soapy hand flexed index finger and slowly extend arrastrándolo on the thumb. The gap is opening between HATH covered by a thin lámina of soapy water. This fluid defies gravity, its molecules remain cohesive and not by surface tension provided by the soap fall. For in the eye similar happens: we need a thin layer of teardrop that it covers all the ocular surface. This surface is not regular, but convex.

And in addition usually it is in upright position. If the teardrop out all water by gravity escurrirÃa “down” toward the lower eyelid. To keep the surface molecules need to do like the soap, which modify the surface tension. These molecules are from fat, and arranged in the surface portion in contact with air. In addition to these molecules fats, we need specialized components to facilitate adherence to tissue below; ie so that moisture “stuck” stay to the cornea and conjunctiva. These molecules are proteins, and placed in depth in contact with tissue. Then, the teardrop has three main components: – Water: the majority of the teardrop is water. At the end of the day, it comes to wet the surface of the eye. – He fatty acids and other molecules lipÃdicas? . They lie more or less in a layer above the water, in contact with air. Superificial maintain the correct tension so that delay evaporación water and stabilize the teardrop.

Also called lipÃdica layer – Proteins: They’re located at the bottom of the tear film, and have an affinity for the surface of the eye and water. It is a form of “paste” the water layer to the fabric. This compositing of protein and water is called mucin (and has structure similar to the mucins and other mucosal surfaces such as the nose function). There are other proteins, such as antibodies and a cell, but we will forget about these components. Here is a picture with several of the glands of which we have spoken: There are many glands with locations, size ± os and different names, let’s look only at the most prominent. Top right looks like a crumpled blue balloon, you get a small ± or tube to the conjunctiva. That is the main lacrimal gland, the largest by far. In addition to producing teardrop, it is able to store it, and when squeezed, tearing occurs when we cry. The main gland produces aqueous component and represented here have blue. In the eyelid, near the tab ± as, reaches the mouth of an elongated gland that HATH painted yellow, which occupies the thickness of the eyelid. These are glands (called meibomian) of fat secretion.

In the circle that leaves the eye diagram is a enlargement of the conjunctiva, where they are a little glands that secrete ± as mucin (shown in green). In the second circle you see a enlargement of the tear film, and follows the same color code before: yellow for fat, blue for water and green for mucin. But we see a representation closer to the reality of the tear film more: The aqueous component, located in the center, occupies the vast majority of the thickness. On the right, those little cells with a fat dot in the center representing the ocular surface cells (epithelium). Between water and epithelium is a small ± a mucin layer, represented by a more clear band. And on the left is at your time represented the fat layer. natural protection against dryness We know the three structures that make up the surface of the eye (cornea, conjunctiva and teardrop). Now we will know the active mechanisms Matiena Ãntegra the surface. Blinking: We know that the teardrop is much more than water; there are components which delay evaporación and form a continuous layer against gravity, and other components that adhere to the eye teardrop. But that is not enough for the teardrop to remain stable in the eye indefinitely. As usual, the teardrop is stable rarely more than 20-30 seconds.

After that time, the teardrop is broken and dry zones are formed (in fact, usually break much earlier for us a tear that is not broken before the 10 seconds is healthy). Therefore, it must be continually replenished, opening and closing his eyes. The flashing “sweep” the surface of the eye, and opening his eyes again resets the tear film. Therefore, we need to blink several times per minute so that we are not left dry eye. One exception is when we sleep: having eyes closed, the teardrop does not evaporate or break, which in principle will not have problems with dryness. Regulación the production of teardrop: The needs of tears are not always the same. The teardrop is being eliminated from the eye through the tear ducts and through evaporación. In hot weather, the teardrop evaporates faster, and just goes with the wind, and the air jets (fan, air conditioning, etc. ). If the elimination of the teardrop is variable, the production of it has to adapt to it. And so it happens: the conjunctiva and the cornea (especially the latter) has nerve endings that detect a dryness. When the eye stays dry through the production of the brain it is stimulated more teardrop. It is an unconscious mechanism, we do voluntarily.

And no relationship with tearing that occurs when we cry. As explained before, when we suffer a strong emotion, or pain, nervous system autónomo commands the main lacrimal gland that “squeeze” to release suddenly all the teardrop that has stored. Causes of dry eye Normally there is no one cause for dry eye, are a multitude of factors that promote this disease. On the other hand, is very often what we call dry eye subclÃnico, ie criteria are dry exploration (eg breaking a tear in 5 seconds) but the patient has no symptoms. In these cases the tear HATH stability “to the limit”, and only factor triggers the whole process. That is, can be something as banal as being a few hours near an air conditioner, start using contact lenses, or anything usual about what may precipitate symptoms of dryness. And the fault is not only the lenses or air conditioning, everyone else factors that exist even before symptoms did not give add. * External factors: Do not depend on the eye, but more and more, given our lifestyle. And we have been discussing before: wind, air conditioning, heating. These elements increase the teardrop evaporación. The pollution air also influences, as the dry atmosphere. We also consider factors external to the eye using contact lenses or eye drops.

And there are some drugs in pills that are able to decrease the production of teardrop. * Internal factors There are three types: – Alteración flicker. If not blink well, the eye is dry compulsorily us. When we are focused on something (reading, computer), unconsciously we blink less. There are diseases that hinder the flicker; for example, a coma patient can stay with your eyes open. In line with this, there are people who when they sleep not entirely close the eyelids, and a small ± or gap is sufficient for them and then dry the area exposed by the day have a lot of trouble. Another example of a disease that affects the flicker is facial paralysis, where half his face is motionless. The eyelids also become paralyzed, and can not be closed (this type of dry eye is called lagophthalmos). – Alteración the aqueous component of the teardrop. The teardrop water constitutes the vast majority, so that most of the glands are responsible for secreting water. Therefore, anything that affects the glands in general, will produce a problem in the first aqueous component. Naturally the glands of our body suffer a deterioration in the year ± os.

After a certain age, it is very common to find pictures of chronic pharyngitis (by dry throat), dry eye, and dryness of other mucous membranes (vaginal, nasal, etc). These fabrics must be moistened suffer chronic irritation because moisture layer is worse than before. The eye is one of the organs most affected by this aging. There are hormonal factors that modify this natural deterioration; for example, in women after menopause much more drying occurs. In short, we can say that misuse, alteration of the aqueous component HATH always present in the dry eyes of the elderly. Furthermore, there are diseases that directly produce a deficit of charged teardrop (more paradigmático example is the syndrome is Sjögren). – Alteración the lipÃdico component: It is a very normal case, perhaps the most common in the case of young people. In this case no amount of teardrop missing, but there is unstable, breaks and evaporates immediately because the fat component does its function. Almost always, the cause is blepharitis, a chronic inflammation of the eyelids edge (where the tab born ± as), that conditions at that level one altered fat secretion occurs. I say, it is very common to find this blepharitis, and find the dry eye clinical data, even if the subject does not have symptoms. This person, now without symptoms but with an unstable teardrop, podrá suffer dry eye symptoms immediately (contact lenses, computer, air conditioning, etc. ) – Alteración of mucinous component: Isolated deficiency of the protein part is uncommon and occur in cases of severe and relatively rare diseases of the eye (conjunctivitis cicatriciales, trachoma, eye burns, Steven-Johnson syndrome, etc)

– Decreased reflex production of teardrop: It may happen that the glands as such are healthy, but do not receive the order to produce enough teardrop. This usually occurs when the brain “not aware” that the eye is being running dry. DecÃamos before the nerves of the cornea (and less of the conjunctiva) are responsible for teardrop warn when necessary, to produce more. If for any reason these nerves do not work, dry eye occurs. The most frequent cause is called corneal anesthesia, are people who can get to touch the cornea without feeling almost discomfort (or any normal person, any touch of the cornea is very annoying and close the eye immediately). The causes of this corneal anesthesia may be an ocular herpes or use of contact lenses.

cold sores microbiological level

cold sores microbiological level introduction The term herpes comes from the Greek “herpein” meaning meander. The epidemiology of herpes virus infections puzzled clinicians for many years. until 1950 when Burnet and Budding showed that the herpes simplex virus could remain latent after the first infection and reactivated to a stimulus. types Herpes viruses are widely distributed in nature and most animal species are natural hosts of more than one. several of which affect humans: herpes simplex type 1 and type 2 (HSV-1, HSV-2), varicella zoster (VZV), cytomegalovirus (CMV), Epstein Barr virus (EBV), human herpes virus 6 (HHV6), human herpesvirus 7 (VHH7) , human herpesvirus 8 (HHV8) and others. structure and classification The structure of the family Herpesviridae virus is very similar and is a fundamental criterion for defining it. In addition to the structure and its ability to establish persistent infections. genome organization is important, its strategic replication, dissemination or intracellular distribution being undetectable to anti-viral antibodies, thus having the privilege of infecting other cells around and leave latent virus.

these types of herpes being similar characteristics different biological similar: All encode enzymes involved in nucleic acid metabolism, DNA synthesis and possibly protein processing. However, all of the proteins encoded by each virus vary. At the core it is synthesized DNA and capsids are assembled, the gain envelope capsids to cross the nuclear membrane. Productive infection always leads to the destruction of the infected cell. All herpesviruses establish latent infections in its natural host. In the latent form the viral genome is in a closed circle and only part thereof is expressed. In 1954, Weller isolated from the same patient virus and varicella zoster; This finding suggested that a single virus generated two different clinical pictures. Persistent feature mind remain in the body and be reactivated is one of the properties shared by viruses belonging to the family of herpesviridae. The genome is herpes virion DNA is double stranded linear localizes to the nucleus, which is surrounded by an icosahedral nucleocapsid and this in turn is covered by an amorphous lipid envelope with viral glycoproteins. The space between the envelope which is the outermost and the nucleocapsid are enzymes and viral proteins called tegument. The virion diameter is 180 to 200 nm. The number of proteins per virion varies, is estimated to be 30 to 35

presented by: Andrea Montoya Cristian Puyo Orlando Ortegón Alphaherpesvirinae, which belong HSV-1, HSV-2 and VZV. The characteristics of this sub-family are: broad host range, short-cycle multiply, spread in cell cultures and destruction of the host, both fast, and ability to remain in a latent form, mainly in sensory cells. HHV6, HHV8 HHV7 and, although they share all of the above features are included in this sub-family. Betaherpesvirinae is cytomegalovirus (CMV); its host range is restricted, its multiplication cycle is long and in cell culture replicated with low efficiency, infected cells exhibit cytomegalovirus (elongated cells), and can remain in latent form in secretory glands, lymphoreticular cells, kidney and other tissues. Gammaherpesvirinae is characterized by its host range restricted to natural host of the virus. An example is the Epstein Barr virus (EBV). They are specific for T or B lymphocytes, in which the infection is latent or lytic without producing infectious progeny. Human viruses are in the three sub-families: Replication

Replication starts with the interaction of viral glycoproteins with the cell receptors resulting in fusion of the virus envelope with the plasma membrane or vesicular membranes depending on the type of virus, thus penetrates the cell cytoplasm nucleocapsid. The nucleocapsid is joined with the nuclear membrane and the nucleus is carried out transcription and replication of the virus; in these processes enzymes and transcription factors that are involved in the viral tegument. They are the most important pathogens of this family. HSV-1 was the first herpes virus first isolated. Both viruses share DNA homology, antigenic determinants and symptoms. The immune response is permanent but is not protective. Herpes simplex types 1 and 2. Pathogeny. The pathogenesis of HSV-1 and HSV-2 is similar, with generally asymptomatic primary infection, although there may be vesicular lesions. The virus initiates infection in the mucous membranes, replicates in cells causing mucoepitelilales lytic infection and spreads to adjacent cells and neurons innervating the site where acute infection began. Epidemiology. HSV-1 is often in overcrowded and poor conditions of hygiene sites have percentages of 90% of the population have antiviral antibodies. HSV-2 depends on sexual activity.

HSV-1 can cause clinical symptoms of varying severity, ranging from gingovoestomatitis, herpes labialis, herpetic whitlow, meningitis, encephalitis with high mortality and herpetic keratitis which in turn can cause blindness. HSV-1 herpes labialis HSV-1 in oral location is transmitted by saliva, kissing, by sharing glasses, toothbrushes and other parts of the body because the virus contact with the skin, it is often autotransmite mainly eyes. HSV-2 is transmitted by vaginal secretions, sexual contact and the infant during passage through the infected birth canal. The active genital herpes in the mother is an obvious risk factor although a large percentage of infected children is the cause herpes symptoms. The possibility that HSV-1 and HSV-2 establish latent infections with asymptomatic recurrences favors transmission, since an infected individual may be transmitting throughout his life. Infective viruses are in the vesicular fluid. Treatment, prevention and control. There are effective antiviral used in the treatment of infections HSV-1 and HSV-2, including famciclovir, acyclovir, valaciclovir. Antiviral not eliminate the virus particles found in neural ganglia, only prevent replication, which can occur reactivations. In these cases, the use of small doses of drugs for a long time, called suppressive therapy is indicated in patients with constant, prolonged or severe outbreaks, although consideration should be given resistance. HSV is transmitted through secretions from lesions, so you should avoid contact during the active lesion Thank you

ΣAlfaherpervirinae gender Simplexvirus Herpes simplex virus gender Varicellovirus VZV Betaherpesvirinae gender cytomegalovirus HCMV gender Roseolovirus Human herpes virus type 6 Human herpes virus type 7 Gammaherpresvirinae. gender Lymphocryptovirus

Epstein Barr virus gender Rhanovirus Human herpes virus type 8 SUMMARY

The “Kiss of the Spider” or Cold Sores

Cold sores, colloquially known as “Kiss of the Spider” is a blister that usually occurs in the outermost part of the lip, only on one side. What are cold sores? Cold sores, colloquially known as “Kiss of the Spider” is a blister that usually occurs in the outermost part of the lip, only on one side. Cold sores may appear one at a time or in bunches and sometimes are filled with liquid. Usually they end up breaking up and a scab forms on them before disappearing. Last one or two weeks and usually require no further treatment. What can cause a cold sore? Cold sores are not caused by the kiss of any spider, but by a virus called herpes simplex. Herpes infection is one of the most common viral infections. This virus can be contracted simply kissing a person with the virus or sharing drinking or eating utensils with it, so it is no wonder that so abound lip blisters. A person who since childhood has been in contact with this virus, you can make the reappearance of these blisters for the rest of your life. This is because even after the blisters dry up and disappear, the virus remains in the body, waiting for the next opportunity to activate and provoke new blisters. When the blisters reappear, they do in the same place as the previous ones.

How I can prevent cold sores? Although cold sores is not a big problem, it is very painful and even unsightly. Therefore one of the recommendations to follow are: Getting enough sleep helps us to strengthen our defenses, eliminate fatigue and stress by allowing us to have stronger immune unsistema to avoid the appearance of cold sores. Try to reduce emotional stress. Stress is one of the main causes of herpes outbreaks. In addition, reducing stress is not only good to prevent herpes but also to improve our quality of life. Use sunscreen on the lips during the summer and also in invierno. Ante exposure to extreme temperatures and sunshine should prevent the occurrence of herpes protecting our lips with adequate protection. Play sports daily. Sport is beneficial to our body and our immune system. In addition it helps us reduce stress, so sport is a healthy and good way to prevent cold sores. Maintain a balanced diet.

Our power is directly related to our defenses. Proper nutrition help us prevent an outbreak of cold sores.

Genital Herpes Treatment Natural Male and Female Truth has Cura

Genital herpes is an STD (sexually transmitted disease). The causative agent is the type 2 herpes simplex virus type 1 and type 1 form cold sores on the face, lips and mouth, but can also cause blisters on the genitals. Type 2 is the main cause of genital ulcers. You can transmit the virus of cold sores on the genitals. This can happen if no precautions are taken or extend to wash your hands through genital or oral sexual contact. The virus does not have to be active to be transmitted. Blisters do not have to be present for the disease to be transmitted to a person. Some Remedies and Treatments for Genital Herpes: –> A relaxing hot bath with Epsom salts or sea salt helps relieve muscle and has the ability to shorten the recovery period takes. While the bath can be relaxing, it also has the potential to spread the herpes virus to other parts of the body. To do this after a shower bath for aviarlo. Be sure to thoroughly clean the shower if you share with someone who does not have herpes. –> The use of warm water and soap also has a soothing effect on injuries.

By keeping the areas that have injuries, which are preventing the spread of infection. Soap is always useful to keep in place infections. This will mimic the same feeling as a hot bath without consuming much time. –> Over generations, a variety of powders have been recommended for its soothing and drying properties. Cornstarch and baking powder are available for use. They will help to keep the area dry, thereby promoting healing. Domeboro powder is another counter medication that has astringent properties, cures many rashes, athlete food, dried and cure herpes sores very quickly. A cotton ball with powders it can be used for a pat on the areas. This dry and reduce itching associated with genital herpes ulcers –> The cup of tea you can enjoy and has another advantage. That bag of black tea can soothe the sores of genital herpes. It not tannin in tea and it has been known for many years that relieves sunburn. It has also been used to relieve symptoms of herpes.


Place the tea bag in hot as you can and then place it on the sores until cool water. –> The medicinal value of aloe vera is well known. It has been documented from 1750 BC to use as a treatment similar to outbreaks of sunburn is very effective. Apply the gel of the aloe vera plant directly to the sores and let it dry. As with all the above elements, it is necessary to keep the area dry to reduce healing time. The cooling effects of aloe help soothe the affected area. –> If you had the flu, your doctor may recommend rest. This is a common task for anyone who is sick. It also applies to outbreaks of genital herpes. When the latent virus rears its head and is a break, relax and allow your body to regenerate help. While it may not cause pain or itching disappear, it will allow your body to focus on the healing process. Do not engage in activities that are using in your body. Avoid exercise or other physical exertion during the attack.

–> Stress has many negative effects on the body. If stress is a relationship, a job or a final exam, you can damage your immune system. Eventually you may notice that their outbreaks are usually connected to a lot of stress. No one can completely avoid stress but to learn how to relieve it will help with your herpes outbreaks. Your immune system helps keep the virus and other diseases under control. Stress management is a valuable tool to reduce the frequency of occurrence of outbreaks. Stress management through daily meditation or other relaxation techniques is valuable for patients with genital herpes. –> It has been suggested on several occasions that the area affected by herpes should be kept clean and dry. Your clothes can be an important factor to keep dry. Cotton is a breathable fabric to be used to cover the area of ​​the sores. Avoid tight pants is also recommended. You can help make the less frequent and shorter break. In conclusion

The resources mentioned above are natural, and will help the treatment of genital herpes and to suppress their symptoms prevent herpes in the body, without the intervention of prescription drugs. Imagine if you can eradicate herpes definitely your body without the harmful side effects of pharmaceutical drugs prescribed by doctors tradicionales. Y best of all in the privacy of your home without having to go where your doctor or penalties friends I invite you to read my story where I same terms as can effectively help rid herpes and also to read the comments at the end of all former patients of herpes that have used this natural and effective treatment. Read My Story Here They came for: cure for male genital herpes remove male genital herpes such as herpes penis dry how to remove male herpes as eliminating the male herpes iodine for genital herpes iodine genitals

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