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1.Trimester acyclovir | Ask the Gynaecologist Dr. Wolfgang Paulus

Additional information: drugs: acyclovir Diseases: Genital herpes Good day Dr. Paulus, I’m 10 + 2 pregnant and have for a few days a recurrent genital herpes outbreak. After clarification of the possible risks of systemic administration of acyclovir by my gynecologist, I have decided to treatment. My question is: 1. whether the baby may carry acyclovir it does not take damage from the 2nd and whether the risk of infection to the unborn not take by is increased? Thanks in advance for the answers and nice evening. of Missy66966 on 08/28/2015

1 Answer: Re: 1. Trimester acyclovir The built-up by the manufacturer registers (Acyclovir Pregnancy Registry 1999) detected 19 congenital anomalies among 596 newborns of women in the first trimester of pregnancy acyclovir systemic (oral, intravenous) had applied and were then followed until birth. With a malformation rate of 3. 2% this collective exceed not the basis risk of 3 to 5%. 2 of 196 neonates reported after intrauterine exposure in II. Trimenon, 7 of 289 newborns after intrauterine exposure in III. Trimenon congenital anomalies, which corresponds to the general basis risk. To prevent transmission in genital herpes the administration of aciclovir before birth is recommended. In two clinical trials fell after such treatment at 46 and 21 pregnant women not infantile disorders (Stray-Pedersen et al, 1990; Scott et al 1996). A systemic use (i. v.

, oral) of acyclovir therefore justified in severe infections in all stages of pregnancy. A local application is possible at any time. A particular risk of infection to the child might continue with maternal herpes in the genital area and vaginal delivery. Reply Dr. Wolfgang Paulus on 30. 08. 2015 Similar questions Dr. Wolfgang Paulus: Hello Dr. Paul, I have a genital herpes with occurring from time to time outbreaks. During pregnancy I had been 2 times a small outbreak, even at the very beginning shortly after ovulation and once in the 15th week. Right now I’m in the 36th .

. . anne-mee 21/08/2015 Keywords: acyclovir Good day, since my childhood I have suffered from frequent herpes attacks that are now in pregnancy again especially frequently (about every 2 weeks, currently 34th Sw). Now I have a concern that to make matters worse my cesarean date or shortly after I . . . Lisabeth 03/27/2015 Keywords: acyclovir Hello Dr Paul! I have a six month old son I silent. Now I have the following problem, I always get a regular herpes on the mouth and nose so far been well 5 times.


Before the SS I took the first tingling equal aciclovir 200mg a 1x daily . . . Sassam 02/13/2015 Keywords: acyclovir Dear Dr. Paul, my son is 5 weeks old and he is exclusively breastfed. I ask 2 questions: 1 / Can I Zoviraxcreme on the cold sore anvwenden, although I still? 2 / There are currently many insects and mosquitoes, and so has my husband Nexa Lotte . . . nada2009 07/25/2014 Keywords: acyclovir

Hello Dr. , my child was born one month prematurely on October 4, 2013. I suffer recurrence with genital herpes, so 1-2 episodes per month. I must therefore take 5x 200mg aciclovir. Is that possible while breastfeeding? As I am currently under a quasi continuous thrust . . . blume1980 13. 12. 2013 Keywords: acyclovir Good day.

Unfortunately I suffer from genital herpes. After numerous other try my dermatologist has chosen a permanent therapy with aciclivir, as each absetzversuch immediately complaints quftreten. My previous gynecologist meant I could . . . ketchup 29. 11. 2013 Keywords: acyclovir Hello, I am tomorrow to represent doctor my gynecologist today. The Gyn has determined that I have a herpes zoster around the wrist. He gave me prescribed acyclovir 800 (Tab. ) These should I take daily 3×1.

Then I get the acyclovir ointment and for . . . Sunshine1012 19/07/2013 Keywords: acyclovir Dear Dr. Paul, we wish much a second child, are no longer so young and so we have not much time. My problem: I in the first half of the cycle (until day 11) due to a herpes simplex infection on the eye acyclovir 800mg and Cefuroxime 500 . . . Cuxnordlicht 08. 03. 2013

Keywords: acyclovir I had on 23/09. my last period and approximately by 08:10. my ovulation. From 08. -14. 10. I had to perform an acyclovir treatment and had at 25. 10 because of a herpes zoster in the face. out I’m pregnant. Does the fetus in this 1-2 SSW already a . . .

Frida103 26/10/2012 Keywords: acyclovir Hello Dr. Paul, due to recurrent genital herpes outbreaks in the last weeks of pregnancy advise me my gynecologist for a Caesarean section. The initial infection has taken place already before pregnancy. Now I read that it is also possible . . . Dana33 17/08/2012 Keywords: acyclovir The last 10 questions for Dr. med. Wolfgang Paulus

AiCuris’ AIC649 Shows Potential to Induce Functional Cure of Chronic Hepatitis B in Preclinical Study

AIC649 is an inactivated Parapoxvirus ovis (iPPVO) particle preparation with distinct immunological activities regulated Including cytokine release and activation of T-cell responses. AiCuris’ AIC649 Shows Potential to Induce Functional Cure of Chronic Hepatitis B in Preclinical Study (German version see below) • Twice weekly treatment with AIC649 Showed antiviral effect similar to twice daily treatment with tenofovir in HBV transgenic mice • Bi-phasic treatment response in chronic hepatitis B woodchuck model • Data published in peer-reviewed article in PLOS ONE Wuppertal, January 5th, 2016 – AiCuris anti-infective Cures GmbH, a leading company in the discovery and development of drugs against infectious diseases, today announced the publication of results from a preclinical study assesing the antiviral efficacy of the Company’s proprietary immune modulator AIC649 as well as its potential to induce functional cure in animal models for chronic hepatitis B. The peer-reviewed article titled “AIC649 Induces a Bi-Phasic Treatment response in the Woodchuck Model of Chronic hepatitis B” was published on December 14, 2015 online on PLOS ONE (www. plosone. org). AIC649 is an inactivated Parapoxvirus ovis (iPPVO) particle preparation with distinct immunological activities regulated Including cytokine release and activation of T-cell responses. Currently, AIC649 is Investigated in a clinical phase I study in patients with chronic hepatitis B. To analyze the antiviral efficacy, hepatitis B transgenic mice were Treated Either twice-weekly with AIC649 or twice daily with “gold standard” Tenofovir or vehicle over a period of 29 days.

Both treatment regimens Showed a significant reduction of hepatitis B virus (HBV) titer Compared to the control group. Noteworthy, the twice-weekly treatment with AIC649 Showed on antiviral effect similar to the twice-daily treatment with tenofovir. The potential to induce functional cure of hepatitis B which of studied in chronically woodchuck hepatitis virus (WHV) infected woodchucks. Animals were Treated twice-weekly with AIC649 or vehicle over to eight-week period Followed by at additional 16-week observation period. Hepatitis surface antigen (WHsAg) served as a marker for functional cure. Treatment of chronic WHV-infected woodchucks with AIC649 revealed a bi-phasic pattern of response. WHV DNA as well as WHsAg Increased and peaked about 2-4 weeks after treatment start to subsequently decline for the rest of the study period. Viremia levels Significantly DECLINED between weeks 16 and 20 and stayed at even lower levels Compared to the control group until the end of the study. The bi-phasic Observed Response to AIC649 treatment can be interpreted: as the result of a physiologically “concerted” reconstituted immune response against WHV and THEREFORE may indicate a potential for inducing functional cure in HBV-infected patients. “AiCuris is currently working on the research and development of Several candidates with the aim to cure viral hepatitis,” Said Dr. Holger Zimmermann, CEO of AiCuris. “The data published on PLOS ONE highlight the potential of AIC649 to induce functional cure. In order to follow-up the promising preclinical data from woodchuck experiments, we have initiated the clinical development in chronic hepatitis B patients.

We very much look forward to speeding up the clinical development of this promising candidate to Provide patients suffering from this life-threatening liver infection with a new treatment option as soon as possible and are open for partnering opportunities. ” The publication can be downloaded from the Company’s website under www. aicuris. com. About Hepatitis B Hepatitis B is a potentially life-threatening liver infection Caused by the hepatitis B virus (HBV). Today the infection darstellt one of the major global health problems and to important occupational hazard for health workers love especially. According the World Health Organization (WHO) estimated 240 million people are chronically infected worldwide (July 2015) with more than 780,000 people dying every year due to complications of hepatitis B, Including cirrhosis and liver cancer. Market experts estimated the HBV market to reach $ 3. 9 trillion in 2016. The medical need for new and innovative therapies to treat chronic infection with HBV is high as – despite Numerous research activities – currently available therapies suppress the virus but Provide cure of the disease only in a slight percentage of patients. About AIC649: AIC649 is a proprietary inactivated parapoxvirus particle preparation. It induces a natural, self-limiting immune response, enhancing immune responses against Appropriate unrelated viruses.

As a novel biological immunomodulator, AIC649 has been conceived as curative treatment for HBV. AIC649 has the potential to become on ideal combination partner with standard of care for patients chronically infected with the HBV. AiCuris is currently testing AIC649 in a clinical phase I study in chronic HBV patients. About AiCuris: AiCuris what founded in 2006 as a spin-off from Bayer and Focuses on the discovery and development of drugs against infectious diseases. Majority investor is the family office of the Dres. Strüngmann. The company is generating drugs against viruses: such as human cytomegalovirus (HCMV), herpes simplex virus and hepatitis B virus (HBV). With respect to bacteria, AiCuris is concentrating on the search for innovative treatment options against life-threatening (multi) resistant nosocomial pathogens. In 2012, AiCuris signed a license agreement with Merck \x26amp; Co (MSD), Which Attracted significant attention being one of the large largest agreements of this kind in the European biotech industry. The agreement covers the development of novel drug candidates against HCMV. Letermovir, the most advanced compound, is currently in phase III clinical trials in patients undergoing bone marrow transplantation. PDF Press Release Contact:


AiCuris anti-infective Cures GmbH Katja Woestenhemke Friedrich-Ebert-Str. 475 / Geb. 302 42117 Wuppertal Phone +49202317 63 0 Fax 202 317 63 1601 +49 Email business@aicuris. com Web www. aicuris. com

AiCuris’ AIC649 shows in preclinical studies for potential functional cure of chronic hepatitis B Twice weekly treatment of HBV-transgenic mice with AIC649 showed antiviral activity similar to a twice daily treatment with tenofovir Two phase treatment success in the woodchuck model of chronic hepatitis B published data in peer reviewed articles on PLOS ONE Wuppertal, January 5, 2016 – The AiCuris anti-infective Cures GmbH, a leading company in the research and development of drugs against infectious diseases, today announced the release of the results of a preclinical study designed to assess the antiviral efficacy of the Company’s immunomodulator AIC649 and its potential for functional cure known in animal models of chronic hepatitis B. The peer-reviewed article entitled “AIC649 performs a two-phase treatment success in woodchuck model of chronic hepatitis B induced” was on December 14, 2015 online in PLOS ONE (www. plosone. org) published. AIC649 is an inactivated Parapoxvirus ovis (iPPVO) with various immunological activities, especially a controlled cytokine release and activation of T-cell responses. Currently AIC649 is being studied in a Phase I clinical trial in patients with chronic hepatitis B. To analyze the antiviral efficacy, hepatitis B transgenic mice were treated over a period of 29 days either twice weekly with AIC649 or twice a day with the “gold standard” or tenofovir with a vehiculum. Both regimens showed a significant reduction of the hepatitis B virus (HBV) titers, compared to the control group. Remarkably, the twice weekly treatment with AIC649 showed antiviral activity similar to the effect of twice daily treatment with tenofovir.

The potential for functional recovery of Hepatitis B was to woodchucks, chronically infected with the woodchuck hepatitis virus (WHV) were infected investigated. The animals were treated over a period of eight weeks twice a week with a vehiculum or AIC649, followed by a further 16-week observation period. Hepatitis surface antigen (WHsAg) served as a marker for functional recovery. The treatment of chronic WHV-infected woodchucks with AIC649 showed a biphasic response pattern. WHV DNA and WHsAg increased and reached approximately 2-4 weeks after initiation of treatment its peak. Then they were down for the rest of the study period. The viremia levels fell between 16 to 20 weeks significantly and remained until the end of the study to an even lower level compared to the control group. The observed biphasic response to treatment with AIC649 can be interpreted as a result of a physiological “tuned”, the restored immune response to WHV and thus indicate a potential for inducing a functional healing in HBV-infected patients. “AiCuris is currently working on the research and development of several drug candidates with the goal to cure viral hepatitis,” said Dr. Holger Zimmermann, Chief Executive Officer of AiCuris. “The data published in PLOS ONE tap the potential of AIC649 forth, a functional cure bring about. In order to pursue the promising preclinical data of woodchuck experiments further, we initiated clinical development of the compound with chronic diseases hepatitis B patients. we look forward to accelerate the clinical development of this promising candidate to treat patients, life-threatening at this liver infection suffer, to offer a new treatment option in a timely manner and are open to establish partnerships for the program.

” The publication can be downloaded from the company’s website at www. aicuris. com. About Hepatitis B Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV). Nowadays, the infection is a significant global health problem and a significant occupational hazard, especially for health care personnel,. According to the World Health Organization (WHO) estimated that world 240 million people chronically infected (July 2015), and more than 780,000 people die each year the effects of hepatitis B, including cirrhosis and liver cancer. estimate market experts that the HBV market will reach $ 3. 9 billion in the year 2016th The medical need for new and innovative therapies for the treatment of chronic infection with HBV is large because – suppress currently available therapies the virus, but to bring about a cure of the disease in only a small percentage of patients – despite numerous research activities. About AIC649: AIC649 is a proprietary inactivated Parapoxvirus which causes a natural, self-limiting immune response that improves an appropriate immune response to non-related viruses. As novel biological immunomodulator AIC649 was designed as a curative treatment for HBV. AIC649 has the potential to be an ideal combination partner for standard therapies for chronic HBV infected patients. AiCuris testing AIC649 currently in a Phase I clinical trial in HBV chronically infected patients.

About AiCuris: AiCuris was founded in 2006 as a spin-off from Bayer and is focused on the research and development of drugs against infectious diseases. Main investor is the family office of Drs. Strüngmann. The company develops drugs against viruses such as human cytomegalovirus (HCMV), herpes simplex virus and hepatitis B virus (HBV). Regarding bacteria AiCuris focuses on research into innovative treatments for life-threatening (multi) resistant nosocomial pathogens. 2012 signed AiCuris a license agreement with Merck \x26amp; Co (MSD) which, as one of the largest such agreements in the European biotech industry, significant attracted attention. The agreement covers the development of novel drugs against HCMV. Letermovir, the most advanced candidate, is currently in Phase III clinical trials with patients undergoing bone marrow transplants. PDF Press Release Contact: AiCuris anti-infective Cures GmbH Katja Woestenhemke Friedrich-Ebert-Str.

475 / Geb. 302 42117 Wuppertal Phone +49202317 63 0 Fax 202 317 63 1601 +49 Email business@aicuris. com Web www. aicuris. com

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