Reactivation of herpes simplex virus type 1 (HSV-1): Risk of Alzheimer? | MiSistemaInmune


After the first infection, herpes simplex virus type 1 (HSV-1) is latently in the trigeminal ganglion, and can be reactivated at any time during the life of the host. Different factors such as temperature, solar radiation, sudden temperature changes or hormonal changes can cause a reactivation of the virus, which is manifested by the appearance of small blisters popularly known as cold sores. Beyond the inconvenience caused by this virus, there are several studies that a possible link between this pathogen and the development of Alzheimer’s disease arises, as in the case of a Japanese study published in January 2013 in the journal ” Biochemical and Biophysical Research Communications “. Here we present some of the results of this study. Reactivation of HSV-1 in the prodromal Alzheimer’s disease In the study they were included 85 people suffering from Alzheimer’s disease, 34 people with mild cognitive impairment amnestic (prodromal stage of Alzheimer’s disease) and 28 healthy people. The avidity index of IgG antibodies to HSV-1, an indicator of reactivation of HSV-1 was measured in order to determine whether there is a relationship between the reactivation and cognitive impairment. The results showed that the rate of IgG antibody avidity anti HSV-1 was higher in people with mild cognitive impairment amnestic than in the other groups included in the study. There are several studies that defined the reactivation of HSV-1 virus as a risk factor in the onset Alzheimer’s. However, this is the first study in which it was found the presence of a viral reactivation in a stage that precedes Alzheimer’s disease, more precisely at the stage of mild cognitive impairment amnestic. Importance of antiviral treatments in preventing Alzheimer’s disease The study also indicates that the rate of IgG antibody avidity anti HSV-1 could be used as a biomarker for early diagnosis of mild cognitive impairment amnestic and Alzheimer’s disease. The study further emphasizes that treatment of HSV-1 could play an important role in preventing the onset of Alzheimer.

To learn more about the contributions of Micro-Immunotherapy in antiviral treatment, we recommend reading the following articles in our blog: “The Micro-Immunotherapy and viruses” and “Contribution of Micro-Immunotherapy in herpes simplex infections “.