Medical Microbiology and Parasitology. Volume II: Section V. Virus: Chapter 61. Herpesvirus: Herpes 6

Available book full text in pdf version The rest of the parts of the book are also available in that format. If necessary you can download the product from Adobe “Acrobat Reader” to display the contents of the book in pdf format by accessing the following link: herpesvirus 6 Herpes 6 virus is the sixth member of the family of human herpesvirus and was first isolated in the laboratory of Robert Gallo at the National Cancer Institute in Bethesda, Maryland, USA, patients with a variety of lymphoproliferative disorders herpesvirus 6 . The human herpesvirus 6 is the sixth member of the family of human herpes virus was isolated for the first time, in 1986, in the laboratory of Robert Gallo at the National Cancer Institute in Maryland, USA from blood lymphocytes peripheral patients with a variety of lymphoproliferative disorders. The isolated virus was a lymphotropic and well distinguishable genetic and antigenic characteristics that differentiate it from all allowed herpesvirus hitherto isolated and placed in the subfamily b herpesvirinae virus. Properties virus The HHV6 genome DNA has a double-stranded, linear, with a size of 155-170 kbp and varies between different isolates. More recent studies, however, have revealed that the HHV6 is more closely related to CMV. It has been shown by analysis of the nucleotide sequence exists 66% sequence homology with CMV. It has been demonstrated by molecular biology techniques the existence of two virus variants: Variant A and B. Both differ in terms of biological, genetic and restriction patterns properties.

Most patients with sudden rash and like febrile illness seem to have HHV6 variant B. HHV6 isolates immunocompromised adult may belong to either variants and at least one patient found both virus variants. The virus has been isolated from peripheral blood mononuclear cells of patients with sudden rash, immunocompromised patients and healthy individuals. It has also been isolated with high frequency from the saliva of HIV-infected patients. The virus replicates in vitro preferably fetal or adult origin phytohemagglutinin-stimulated T lymphocytes. In infected cells they can be detected viral capsids at day 3 and mature virions after 5 days. Pathogeny The main target cell HHV6 appear to be CD4 + lymphocytes. Macrophages are persistently infected and may be an important reservoir. Transformed B lymphocytes, natural killer, megakaryocytes, glial cells, fibroblasts and epithelial cells are able to support the replication of certain strains of virus. Frequent isolations saliva herpesvirus 6 suggest that the virus resides and is removed from the salivary glands. The viral DNA and antigens have been identified in epithelial cells of the salivary glands and from different regions of the upper respiratory tract. So far it is assumed that herpesvirus 6 infection is transmitted by horizontal transmission, and there is no evidence of vertical transmission.

It has been suggested that the Herpes 6 can persist in monocytes / macrophages in a dormant state, although these are not exclusive primary site in vivo latency. The exact mechanism of reactivation of herpes 6 is not clear yet. It has been shown, however, that various types of transactivation can occur between herpes virus 6 and others including CMV, EBV, measles virus and HIV. Is a lymphotropic virus that infects susceptible individuals during the first year of life and generally cause lifelong latency. In a percentage variable, primary infection is followed by an acute illness of short duration, sudden rash. Older individuals may suffer an illness similar to mononucleosis or Kikuchi-Fujimoto disease. It is also capable of causing a wide range of hematopoietic, lymphoid and autoimmune disorders which have been associated with high titers of antibodies to herpes virus 6 and of which the virus has been isolated. These diseases include atypical polyclonal lymphoproliferation of Hogkin disease, chronic fatigue syndrome and systemic lupus erythematosus. General characteristics The herpesvirus 6 virus is ubiquitous in the human population. Infection occurs within the first two years of life; occasionally it is resulting in an acute febrile illness with or without sudden rash. Maternal antibodies are generally present at birth and decline in the first months of life. Seroconversion occurs in most cases between 6 and 18 months and the titles are high in adolescents.

Frequent isolations herpesvirus 6 of saliva suggests that the virus resides and is eliminated from the salivary glands. The viral DNA and antigens were identified in epithelial cells of the salivary glands and from different regions of the upper respiratory tract. So far it is assumed that herpesvirus 6 infection is transmitted by horizontal transmission and there is no evidence of vertical transmission. The most significant property of herpesviruses is their ability to produce a latent infection. During the acute phase of the disease, herpes DNA has been detected in 6 CD4 lymphocytes. During the convalescent phase of exanthem subitum 1. 5 to 2. 5 months after the onset of disease viral DNA is present in a population of adherent cells (monocytes), but not in lymphocytes. It has been suggested that the herpesvirus 6 may persist in monocytes / macrophages in a dormant state, although these are not exclusive primary site in vivo latency. The exact mechanism of reactivation of herpes 6 is not clear yet. Reactivation of the virus seems to occur spontaneously with other herpesviruses in the 5 to 20% of clinically asymptomatic population. It has been shown, however, that various types of transactivation can occur between herpes virus 6 and others including CMV, EBV, measles virus and HIV. clinical data


A variety of clinical disorders have been described as that may be associated with herpes infection 6. Based on current knowledge, which have been insufficient, diseases associated with herpes infection 6 have been classified into 2 groups: diseases caused by herpesvirus 6 infection and disease possibly associated with herpes 6, but without etiologic relationship clearly identified. The first group includes the sudden rash and child-like febrile illness with or without rash, infectious mononucleosis in the absence of heterophile antibodies and cases of Kikuchi disease. The second group consists of certain autoimmune disorders, chronic fatigue syndrome and lymphoid hematopoietic and proliferative diseases. In addition, they have been reported cases of fulminant hepatitis in immunocompromised patients and has been associated with reactivation of herpesvirus 6 and retinitis interstitial pneumonitis. Sudden rash. It is an acute disease that affects mainly small and young adults and is characterized by a short period of high fever (1-5 days) and the appearance of a rash which coincides with the period of defervescence usually occurs in summer and affects both sexes equally. It may be accompanied by sore throat and runny nose. There is absolute neutropenia with lymphocytosis of up to 90% and presence of atypical lymphoid cells with a plasmacytoid cytoplasm. The prognosis is good and does not require treatment. Other febrile illnesses. The virus has been isolated from children with acute febrile disease and otitis and in a percentage of cases the rash may be present. Other symptoms include malaise, irritability, nasal congestion, diarrhea, cough, vomiting.

The picture is benign and does not last more than 4 days. Infectious mononucleosis heterophile absence of Acs. It occurs frequently as a result of reactivation of latent infection by HHV6. The age of patients is the same as those with EBV mononucleosis. It is characterized by an indistinguishable exudative pharyngitis or membranous classical mononucleosis. Lymphadenopathy unlike the MI by the VEB, which tend to resolve in 11 days, may be present to more than 30 days and be associated with hepatosplenomegaly, lymphadenopathy retroperitoneal and blurred vision. Kikuchi disease: This is a histiocytic necrotizing lymphadenitis that has been recently reported. Reported cases come from Japan, Europe, the United States and other parts of Asia. Patients have not painful lymphadenopathy in neck and may or may not be accompanied by sore throat, fever, chills and myalgia. The age of patients ranges between 10and 60 years, with a predominance in 20. Other possible locations of the lymph nodes are axillary, and supraclavicular brachial region. Lymphadenopathy persist for months and can move on to a phase of chronic fibrosis. The prognosis with or without symptomatic treatment is good.

Transplant recipients. Virus reactivation in transplant recipients can lead to interstitial pneumonitis, encephalitis and rejection in some cases. Chronic fatigue syndrome. abruptly starts with a like syndrome accompanied influenza respiratory symptoms and / or gastrointestinal, fever, myalgia, arthralgia, fever, sore throat, unexplained general muscle weakness, excessive fatigue and prolonged postejercicios, neuropsychological symptoms, sleep disorders, among others. These are presented in various combinations, and due to variability among individuals, often the diagnosis of this syndrome is a problem for most doctors. Sjogren’s syndrome. It is an autoimmune disorder characterized by chronic inflammation with infiltration of exocrine glands that can progress to malignant lymphoma. The disease can occur in a primary form, without being associated with connective tissue disease or a secondary form attached artriris rheumatoid, systemic lupus erythematosus or other connective tissue disease. The characteristic and high diagnostic value triad is keratoconjunctivitis, xerostomia and polyarthritis. Any combination of these symptoms can be used for diagnosis. Immunological disturbances consist of functional defects, hyperactivity of B cells and natural killer deficient cells T cells. They can detect a variety of autoantibodies. Systemic lupus erythematosus.

The etiology of this disease is unknown and considered to be a viral infection, altered immune reactivity and genetic predisposition are responsible for the onset of disease. Many infectious agents, they can be imputed to cofactors in disease pathogenesis and herpesviruses are among them. Serological studies have shown high antibody titers against HHV6 in patients with systemic lupus erythematosus. Furthermore they have been detected in biopsy specimens of skin infected with the virus and in primary cultures of peripheral blood lymphocytes of these patients CD4 + / CD38 + was detected the virus genome by in situ hybridization and Acs by immunofluorescence. HHV6 and AIDS. Numerous virus isolates have been conducted in patients with AIDS. Because both viruses share target cell CD4 + lymphocytes, it is suggested that HHV6 is an important step in the progression to AIDS stage cofactor. This virus can cause retinitis in these patients. atypical lymphoproliferative disorders. Among the lymphoproliferative disorders related to infection by herpes virus 6 are: atypical polyclonal lymphoproliferation, non-Hodgkin lymphoma, hemophagocytic syndrome, among others. Finally, some researchers report the discovery of high antibody titers against herpes 6 in patients with myelodysplasia and chronic myeloproliferative syndromes (osteomielofibrosis and chronic myelogenous leukemia). Diagnosis The HHV6 can be isolated from patients with sudden rash during the febrile phase of the disease.

Samples are employed more often peripheral blood monocytes and saliva. These are inoculated on mononuclear cells prestimulated cord phytohemagglutinin. Furthermore, they can be used cell lines as HBS 2, the Sup T1 and Jurtka for variant A virus, and Molt 3 for variant B. The cytopathic effect appears between 5 and 9 days after inoculation the virus and is in rounding of the cells increase in size, merging with multinucleated giant cell formation and vacuolation. The virus can be confirmed by electron microscopy, immunofluorescence and immunoenzymatic assays for detecting antigens and molecular biology methods such as PCR and hybridization enable the detection of viral DNA in samples and in culture. Serological diagnosis is made by ELISA and indirect immunofluorescence using cells infected by the virus lymphoid origin. Epidemiology The herpesvirus 6 virus is ubiquitous in the human population. Is a lymphotropic virus that infects susceptible individuals during the first two years of life and generally cause lifelong latency. In a percentage variable, primary infection is followed by an acute illness of short duration, the sudden rash (children roseola or “sixth disease. ” The older individuals may suffer an illness similar to infectious mononucleosis or Kikuchi disease -Fujimoto. it is also capable of causing a wide range of hematopoietic, lymphoid and autoimmune disorders which have been associated with high titers of antibodies to the herpes virus 6 and of which the virus has been isolated. Maternal antibodies are generally present at birth and decline in the first months of life.

Seroconversion occurs in most cases between 6 and 18 months and the titles are high in adolescents. high titers of antibodies to herpes 6 have been observed in a number of diseases including immunocompromised persons; This suggests that reactivation of latent infection and exogenous reinfection occur with herpesvirus 6. So far it is assumed that herpesvirus 6 infection is transmitted by horizontal transmission through oropharyngeal secretions and there is no evidence of vertical transmission. Treatment Most primary infections do not require specific treatment. In case of related transplant recipients, fulminant hepatitis, hematopoietic disorders, autoimmune diseases lymphoid either the use of some antiviral. The virus is sensitive to foscarnet, ganciclovir and acyclovir relatively resistant.

Orthomol immune for genital herpes

Orthomol immune for genital herpes, herpes mitAggressivität genitals, nightmares, hallucinations, headache, irritability, heartburn Hello, I once had the post: acyclovir 400 genital herpes 10 years Registered on 05. 09. 2012 as a record 47139 written here. Now I want to add this post yet with any important information as a review, for all people, young or old, who are dealing with –Herpes Genitales– and suffer from frequent outbreaks. Chronic reszidivierenden Herpes Genital I have for the time mentioned side effects, the more complex were (bowel problems, such as burning during bowel movements and ever while taking time somehow bowel problems / pain). Then I noticed a change in sleep, so I dreamed more intensely while taking time, I did not feel uncomfortable.

But the night startled suddenly, this was quite strange, I got increasingly nightmares where I startled night. Now I took 2 years Orthomol immune, it was suggested to me as an attempt. On my question: Since I can not feed more balanced and am therefore not as well protected, I wanted to ask whether there is something that I here something could help to strengthen my defense, a sort of supplement. There was me by the doctor of internal, recommended as an attempt the Othomol immune. I began to take granular packet. To dissolve in water. I took it and had a feeling it would do me good. The herpes outbreaks were (I think) less. But they still came often. Since the taste of Garnulates for me and I’m not a wimp, just was sometime disgusting, I wrestled through me to ask in a pharmacy for an alternative preparation. That was not easy because my main wish was: Something not so disgusting disgusting taste, if you take it to be. And yet, the pharmacist was in the system, a preparation which has similar active ingredients and were offered with extra- taste. Well you could say: any flavor, the main thing it helps.

But I had the impression it does not really help and for this it was still disgusting when drinking. So they recommended me a direct pellets from Ortho-Expert. Small sachets. You open a bag and makes the granules on the tongue and it dissolves and it’s taste for me 100% better. Well, now, however, the most important for me part of this experiment. I took it a few weeks, not every day, but I took it every 2nd (memory). Then I set it down. And had several months no more Herpes outbreak. I went to the pharmacy gave this feedback and ordered me back a pack. They recommended me here first not to take the product to just wait until the next outbreak comes back. Thus, the body simply once again collaborates with himself and can make something and not always only get the stuff. Also I heard. A few weeks later I got then again an outbreak.


Basic was great stress intrapsychically, so more than usual, intense precisely. I also took the forerunners with not the same because I had nothing long and not noticed: For the harbingers: -Drag In the penis (for days) – Tingling in the penis – Pull, pain in the testicles (sometimes right testicle or left nut) -Drag In thighs (above ground) -Schmerzende Lymph nodes in the groin area left and right -Yes Also lymph node pain in the armpit area (although it is claimed, it can not be) -A headache I want to send this experience all herpes genital sufferer. This preparation has my relapse positively influenced, therefore minimized. For this purpose, however, is important reasonably good to eat.

A mere ingestion would be something stupid. Given the price-performance ratio compared to Orthomol immune totally super, according to my understanding. In a package of granules (Cranberry) are believe 15 sticks. and it costs around 15 euros. Sometimes the prices fluctuate. So I thought at first, it is because the name “Immune Boost” just again a promotion of any remedies. But mitlerweile the name I do not care, it helps me and also tastes still acceptable and not deviant / disgusting and it is inexpensive compared to the Othomol immune. The extent to which the effect substances are different, this must always compare for yourself. In any case, I would recommend here to consult the doctor for this purpose even if it is taken for several months. Well and now to Fucidin ointment I can highly recommend this highly effective ointment. It is a skin antibiotic and helps me really fast

heal, even with sores on the penis (microcracks or Red points) it is well below. It helps the eruption on the skin and the outbreak is more quickly away again. Of course, at least 1 x per day making it and not forget the hygiene before. And also important, constitutes a chain with disinfecting. I think if you anfässt down there during an outbreak and einsalbt should then not in the eyes (random, Weil’s itch) rub . . . . so always disinfect hands. I suppose here Sterilium Virugard is effective against herpes viruses. Well, I hope you have taken a little courage. Of course, is important to say, it just all seems different for each person, to each his own way.

Nevertheless, good luck! And remember: There are people who believe that stress can harm them. But they often know nothing about stress. Nice to much corporal proximity can mean stress, I’ve found. So by “too much” . . . it came to outbreaks. It took me years before I learned the trigger yourself. But that does not succeed ever . . . because I’m like everyone else, often distracted from everyday life .

. . You Good Everything! I will someday daily here. Maybe other people do also positive experiences. I would be happy for you. Best regards! Ps: Exercise is important, so go shopping by bike or drive around. Where I am less moved at that time were the outbreaks even more. Yourself and look at his life holistically and you can safely for themselves way out finden. mehr from chronic herpes Drama . . .

Herpes – The PSVR informed

Current herpes cases in the Rhineland – avoid panic (18/02/2015) The herpes virus is not unduly dreaded disease at horse owners. You can trigger abortions, leading to respiratory infections and diseases of the nervous system in high pregnant mares. In some cases, the disease or its concomitants runs also fatal. By date confirmed cases of the disease in an operation in Wermelskirchen a certain panic has now emerged throughout the national association and also beyond its borders. Due to an often inadequate flow of information and a lack of background knowledge regarding the disease, the rumor mill is in the current situation trigger great fear and partly also numerous overinterpretations. “We are dealing with a very serious problem,” says PSVR Board Rolf-Peter foot. “However, it is immensely important to have a panic to prevent,” said the experienced horseman, who together with his team from Pferdesportverband Rheinland has striven in recent days to bring the actual facts on the table in order to provide clarity. These included numerous discussions with experienced veterinarians and animal hospitals and various stables operators and horse owners. There is currently throughout the national association an operation (in Wermelskirchen), which has confirmed the outbreak of the virus. After consultation with one of the veterinarians treated can be assured that the precautions by the plant operator and the horse owners concerned are maximum. The accommodated in the affected barn tract horses are under absolute box rest and must leave the building at any time. So could be prevented so far also, that there was an outbreak of the disease in accommodated in another barn tracts horses.


Furthermore, the entire operation is since the outbreak of disease exclusion zone for humans and horses from outside. The animals are under intensive veterinary care. Three animals were taken to a veterinary clinic, are passed to the consequences of the disease. Current knowledge has so far only in one of these dead horse herpes virus detected. By implemented measures, which are carried out strictly for about four weeks, the treated veterinarians are confident of getting the virus in a timely manner in the handle and to the precautions in the near future loosen again. For the fears and concerns of both horse owners, veterinarians and PSVR Board Rolf-Peter foot have a basic understanding, but it is in most cases according to the experts rather unfounded. Because of the virus, the latent carrier accounting for about 80 percent of the total population is not transmitted over the air. The activation or re-infection via droplet infection. It is the responsibility of the individual horse owners, veterinarians and farriers who were in contact with a diseased horse, to take specific precautions. The infection by indirect contact, that is about people and objects, for example, is in the frequency, however, significantly lower than the activation direct contact. In the current situation, some riding facility operators have declared to protect their Einstaller their operations as restricted zone. This has led to numerous rumors circulating of other cases – these are they exclusive precautions! How similar was confirmed by several veterinarians, these precautions are in the current situation, however, not mandatory.

“It is important at the moment to keep a clear head and not to be put through the potentiating effect of social media platforms in unnecessary panic,” says Rolf-Peter foot. “We as Pferdesportverband will keep the subject of course in the eye and are in constant contact with the various veterinarians. Should there be more confirmed cases of the disease, we will inform you and also in a further spread of the disease respond appropriately” so the PSVR Board. It is strongly advised to consult with a suspected case to the veterinarian and clarify well in advance of any issues relating to security measures with appropriate specialists. Against the implementation of upcoming equestrian events consist of a medical perspective, according to matching information of all surveyed veterinarians no concerns. Hence the upcoming weekend Halle terrain ride in Pferdesportzentrum Rheinland is performed based on the present knowledge. Thus, there are also concerns about conducting Tournament Events no medical concerns. For more information on herpes, see: https://www. zoetis. de/conditions/pferde/equines-herpesvirus. aspx http://www.

pferdeklinik-cronau. de/info/info_herpes. htm http://www. msd-tiergesundheit. de/News/Fokusthemen/Equines_Herpesvirus/Einleitung. aspx

Again herpes, this time in the nose – infection – med1

07:04:12 23:15 Hello dear forum members. Usually it is so that herpes always announces with this typical itching, so I can usually “confirm” a forthcoming herpes infection immediately. So it was today, but this time the matter is apparently a little more complicated . . . I immediately recognized from this typical itching that probably my right nostril will be affected again. But no, much worse: This time sitting herpes IN nose. The bad thing is just that I have read that such an infection in the nose to the brain “wander” can thereby meningitis could occur! I just been hit by countless forums and even read by some that their herpes as deeply seated in the nose that they no longer even turn come with a cotton swab. Whereas my herpes “only” near the front, so sitting in the Näse of receipt. But he sits up in the nose, and that worries me. After the contact is indeed characterized added with the mucous membranes, which the virus could spread – possibly to the brain .

. . Had someone already times herpes in the nose? Should supposedly be rather unusual and occur more rarely, I have read. Is my fear really justified, or I make myself a little crazy? And what I can do, especially against herpes? Can I have a salve it lubricate, though he sits in the nose? Best wishes and a good night wishes budgie. X {WelleSnsi (tticxhX 08:04:12 18:44 This time sits the herpes IN nose. The bad thing is just that I have read that such an infection in the nose to the brain “wander” can thereby meningitis could occur!

Is my fear really justified, or I make myself a little crazy? Do not be mad, I have for years repeatedly herpes in the nose. Although this is quite uncomfortable and annoying because he needs to heal always much longer with me in the nose, but I think that this is not dangerous. And what I can do, especially against herpes? Can I have a salve it lubricate, though he sits in the nose? Of course you can because it also lubricate herpes ointment. I always try that with a cotton swab. S’chnee, witch