Cold Sores: Symptoms that can not miss

What are cold sores? Cold sores are infections on the lips, mouth, gums with a virus called herpes simplex. You develop a small blisters and are very painful, also called fever blisters. Cold sores are caused by herpes simplex type 1 virus, being a common disease. Many people are infected with this virus all over the world High chances of contagion Initial infections cause ulcers in the mouth or around the lips. The virus disappears when the infection remains dormant in nerve tissue of the face. Sometimes the herpes virus produces a febrile appearing in the same part, not being of gravity. The cold sore virus is highly contagious and is spread by intimate or personal relationships. Through the personal items that are shared as towels, razors, and other dishes. Also oral sex without condom use, transmits cold sores. Symptoms of Cold Sores

-The First sign of cold sores is usually mild, but sometimes can be severe. After 1 to 3 weeks are the first symptoms of cold sores, when it has been in contact with this virus. – This virus is getting easier in children. Symptoms in later episodes are usually milder. – It appears with a sore throat, fever lasting five days or less and usually occurs before the blisters appear. inflamed lymph also sometimes. – Relapses or latent periods may occur by stress, sun exposure or more causes more. – Before lesions appear you may feel burning, increased sensitivity in that area, tingling sensations. – Blisters or vesicles containing a clear, yellowish liquid. These blisters are painful, eventually rupture and drain. Treatment of cold sores – Through a growing health professional determines the diagnosis. – Without treatment the symptoms disappear within two weeks.

The remedies for oral, antiviral pathway shorten symptoms and reduce pain. – Blisters caused by cold sores may appear again and again, so it is best to avoid taking medication when it will reappear. – You can use topical antiviral creams must be applied every two hours. – To prevent cold sores should avoid contact with cold sore lesions. It should maintain complete hygiene and wash personal items with boiled water and hot before reuse. – Blisters should be washed with antiseptic soap and water so that the virus does not spread by other areas of the body, If ice is applied on the affected parts can calm the pain. – You must use a moisturizer protective balm to not let the lips from drying and exposure to the sun unless it is protected by sunscreen. It is not fair that you resign yourself to live with injuries and you can avoid social and sexually condition. It cure your cold will give you the foundation you need for your body does not suffer more injuries caused by the virus. Do not waste another day. Order your copy of Cure Your Herpesy fight begins today.

Frequent eye infections and their treatment

There are several eye infections that occur with some similar symptoms. Treatment measures depend on the cause of the infection and the severity of the disease. Table of Contents Conjunctivitis Conjunctivitis (or conjunctivitis) is the eye infection that occurs most often. An inflammation of the conjunctiva can be triggered by various factors. Thus, for example infection by viruses, bacteria or fungi can be triggered. If so, then there is a risk of infection for others. Is it in conjunctivitis but is a non-infectious disease, then there is no such risk of infection. The trigger for a non-infectious conjunctivitis can be very diverse. So come as a possible cause, for example, questioning banal environmental influences. Long working at the computer, drafts, bright light or UV rays can the conjunctiva as well as irritating fumes or cold air. Even on a transition from chlorinated pool, the conjunctiva react with inflammatory symptoms.

In addition, a pollen or house dust allergy, chickenpox and measles (teething), a damaged cornea, refractive errors, or simply the wrong glasses can lead to inflammation of the conjunctiva. The symptoms Symptoms of conjunctivitis are usually reddened, itchy, burning and watery eyes. The eyelids and conjunctiva may swell. with an infection often arises also feel as a foreign body would be located in the eye. In addition, the eyelids in the morning are often bonded by the leaked secretions. treatment options Symptoms of conjunctivitis express themselves mostly as described above. The trigger or the cause of the inflammation are irrelevant. However, it is in the treatment of infection always depends on whether the inflammation was triggered by an infection or if it is non-infectious origin. In a non-infectious conjunctivitis, triggered for example by drafts, the symptoms usually disappear after a few days off by itself. If the symptoms but triggered by an allergy, so the eyes with anti-allergic eye drops or eye ointments can be treated. In addition, of course, should the underlying disease (allergy) are treated.

In inflammation, triggered by bacteria, fungi or viruses, antibiotic treatment is recommended. Treatment with antibiotics will usually locally, in the form of eye ointments or eye drops instead. The inflammation of the cornea The inflammation of the cornea occurs much less frequently than conjunctivitis. However, this eye infection is much more dangerous to the eye, because through them, the vision may be impaired. The causes of this inflammation can be very diverse again. One possible cause often affects contact lens wearers who wear their lenses for a long time. This allows the cornea to be attacked. This in turn can cause bacteria colonize on the cornea that can damage the cornea on. Even dry eyes, in which insufficient tear fluid is formed are susceptible to bacteria that can damage the cornea. In addition, fungi and herpes viruses can alter the corneal inflammation. In addition, injuries from foreign objects come into question as the cause. The inflammation of the cornea can also be due to another underlying disease (such as a rheumatic disease) occur.

The symptoms Symptoms of inflammation of the cornea are those of conjunctivitis are often very similar. The eyes are red, burning and pain. In addition, here is often a strong foreign body sensation exists. Unlike conjunctivitis, vision may be impaired at a corneal inflammation. treatment options Treatment of inflammation of the cornea depends on the cause. Are viruses responsible for the infection, then there will be a treatment with tablets, infusions or eye drops, which inhibit the growth of viruses. In bacterial infections is treated with antibiotics in the form of eye drops or eye ointments. If a fungal infection, the cause of the inflammation of the cornea, so usually an operation must be performed. In this the affected layers of the cornea are removed. This can be especially problematic when the deeper layers of the cornea already affected. The iritis

The inflammation of the iris is extremely rare. In addition, it often occurs in connection with inflammation of the vitreous. The cause may be, for example a natural defense reaction to a tick bite. But serious underlying conditions such as arthritis can have an iris lesion result. The symptoms The symptoms often show up in the form of light sensitivity, eye pain, decreased vision, and a change in color of the iris. treatment options In bacterial infections is treated with antibiotics. Moreover, can be treated with anti-inflammatory agents. In severe infections often a cortisone injection under the conjunctiva must be.

BIKER Register – Publications

Publications Here you can find scientific publications BiKeR project in reverse chronological order: Long-term safety of etanercept and adalimumab Compared to methotrexate in patients with juvenile idiopathic arthritis (JIA). Klotsche J, Niewerth M, Haas JP, Huppertz HI, zinc O, Horneff G, Minden K. Ann Rheum Dis. 2015 April 29 pii: annrheumdis-2014-206747. doi: 10. 1136 / annrheumdis-annrheumdis-2014-206747 Incidence of herpes zoster infections in juvenile idiopathic arthritis patients. Nimmrich S, Horneff G. Rheumatol Int. 2015 Mar; 35 (3): 465-70. doi: 10.

1007 / s00296-014-3197-6. Epub 2015 January 13 [Current news from the BIKER register]. Horneff G, K Minden, Földvári I, Onken N, wind sound D, Hospach A, G Ganser, Klotsche J, Becker I; BIKER Register Study Group. Z Rheumatol. 2014 Dec; 73 (10): 897-906. doi: 10. 1007 / s00393-014-1397-9. German. Safety and efficacy of etanercept in children with juvenile idiopathic arthritis below the age of 2 years. Wind noise D, Müller T, Becker I, Horneff G. Rheumatol Int. 2015 April; 35 (4): 613-8.

doi: 10. 1007 / s00296-014-3125-9. Epub 2014 Sep 11th Predictors of response to methotrexate in juvenile idiopathic arthritis. Albarouni M, Becker I, Horneff G. Pediatr Rheumatol Online J. 2014 Aug 13; 12: 35th doi: 10. 1186 / 1546-0096-12-35. eCollection, 2014. Safety and efficacy of etanercept in children with the JIA categories extended oligoarthritis, enthesitis-related arthritis and psoriasis arthritis. Wind noise D, Müller T, Becker I, Horneff G. Clin Rheumatol. 2015 Jan; 34 (1): 61-9.

doi: 10. 1007 / s10067-014-2744-6. Epub 2014 Jul 18th Efficacy and safety of adalimumab as the first and second biologic agent in juvenile idiopathic arthritis: the German Biologics JIA registry. Schmeling H, K Minden, Földvári I, Ganser G, T Hospach, Horneff G. Arthritis Rheumatol. 2014 SEP and 66 (9): 2580-9. doi: 10. 1002 / art. 38741. Definition of improvement in juvenile idiopathic arthritis using the juvenile arthritis disease activity score. Horneff G, Becker I. Rheumatology (Oxford).

2014 July; 53 (7): 1229-34. doi: 10. 1093 / rheumatology / ket470. Epub 2014 Mar. 4 Predictors of response to etanercept in polyarticular-course juvenile idiopathic arthritis. Geikowski T, Becker I, Horneff G; German BIKER Registry Collaborative Study Group. Rheumatology (Oxford). 2014 July; 53 (7): 1245-9. doi: 10. 1093 / rheumatology / ket490. Epub 2014 Mar. 4

Improvement in health-related quality of life for children with juvenile idiopathic arthritis after start of treatment with etanercept. Klotsche J, K Minden, Thon A, G Ganser, Urban A, Horneff G. Arthritis Care Res (Hoboken). 2014 February; 66 (2): 253-62. doi: 10. 1002 / acr. 22112 Efficacy and safety of oral and parenteral methotrexate therapy in children with juvenile idiopathic arthritis: an observational study with patients from the German Methotrexate Registry. Small A, Kaul I, I Földvári, Ganser G, Urban A, Horneff G. Arthritis Care Res (Hoboken). 2012 SEP and 64 (9): 1349-56. doi: 10. 1002 / acr.

21697 Development of inflammatory bowel disease in patients with juvenile idiopathic arthritis Treated with etanercept. van Dijken TD, Vastert SJ, Gerloni VM, Pontikaki I, Linnemann K, Girschick H, W Armbrust, Minden K, Prince FH, FT coccus, Nieuwenhuis EE, Horneff G, WulffraatNM. J Rheumatol. 2011 July; 38 (7): 1441-6. Epub 2011 April. 1 Summary National JIA register in the Netherlands, Germany, Finland, Denmark and Italy were searched for JIA patients who were sick also to inflammatory bowel disease (IBD). It was investigated whether treatment with etanercept lead in JIA patients to higher incidence rates of IBD. 13 cases of IBD in JIA patients were found in 1999 by 2008. The IBD coincidence with JIA patients with etanercept treatment was 362 per 100,000 patient years, 43 times higher than in the general pediatric population. Report on malignancies in the German juvenile idiopathic arthritis registry.

Horneff G, Földvári I, Minden K, D Moebius, Hospach T. Rheumatology (Oxford). 2011 Jan; 50 (1): 230-6. Summary Reports of malignancies in children who were exposed to TNF inhibitors, raise questions with regard to increased risk for malignant lymphomas. In German JIA registers found between 2001 and 2009 Classificação de 5 the total 1260 patients who had a malignancy. All 5 patients were exposed to a variety of cytotoxic agents (inter alia MTX, LEF, AZA, CSA) before they were treated with TNF-α blockers. Malignancies have been observed for a period of treatment with etanercept from 3 weeks to> 6 years. While in some of the patients the treatment time with TNF blockers was too short to determine a recognizable reference, the long preliminary treatment could be causative for other patients studied. JIA patients treated with biologics, or cytotoxic agents should be accompanied observed thoroughly malignancies – in the longer term, in adult life. Complete control of disease activity and remission induced by treatment with etanercept in juvenile idiopathic arthritis. Papsdorf V, Horneff G. Rheumatology (Oxford).

2011 Jan; 50 (1): 214-21. Erratum in: Rheumatology (Oxford). 2011 April; 50 (4): 814 Malignancy and tumor necrosis factor inhibitors in juvenile idiopathic arthritis. Horneff G. Z Rheumatol. 2010 Aug; 69 (6): 516-26. Review. German. Updated statement by the German Society for Pediatric and Adolescent Rheumatology (GKJR) on the FDA’s report Regarding malignancies in anti-TNF-treated patients from Aug. 4, of 2009. Horneff G, T Hospach, Dannecker G, Föll D, Haas JP, Girschick HJ, Huppertz HI, Keitzer R, Laws HJ, Michels H, K Minden, Trauzeddel R. Z Rheumatol.

2010 Aug; 69 (6): 561-7. German. Safety and efficacy of once weekly etanercept 0. 8 mg / kg in a multicentre trial in 12 week active polyarticular course juvenile idiopathic arthritis. Horneff G, Ebert A, S Fitter, Minden K, Földvári I Kümmerle-Deschner J, Thon A, Girschick HJ, Weller F, Huppertz HI. Rheumatology (Oxford). 2009 August; 48 (8): 916-9. Epub 2009 May 29th Improvement of functional ability in children with juvenile idiopathic arthritis by treatment with etanercept. Halbig M, Horneff G. Rheumatol Int. 2009 Dec; 30 (2): 229-38 Safety and efficacy of combination of etanercept and methotrexate Compared to treatment with etanercept only in patients with juvenile idiopathic arthritis (JIA): preliminary data from the German JIA registry.

Horneff G, De Bock F, Földvári I Girschick HJ, Michels H, D Moebius, Schmeling H; German and Austrian Paediatric Rheumatology Collaborative Study Group. Ann Rheum Dis. 2009 April; 68 (4): 519-25. Epub 2008 April 15 Safety and efficacy of etanercept in children with juvenile idiopathic arthritis below the age of 4 years. Tzaribachev N, Kuemmerle-Deschner J, M Eichner, Horneff G. Rheumatol Int. 2008 August; 28 (10): 1031-4. Epub 2008 Mar 28 Safety and efficacy of once-weekly application of etanercept in children with juvenile idiopathic arthritis. Kuemmerle-Deschner JB, Horneff G. Rheumatol Int. 2007 Dec; 28 (2): 153-6.

Epub 2007 Jul 20th Etanercept and uveitis in patients with juvenile idiopathic arthritis. Schmeling H, Horneff G. Rheumatology (Oxford). 2005 August; 44 (8): 1008-11. Epub 2005 April 26 The German registry etanercept for treatment of juvenile idiopathic arthritis. Horneff G, H Schmeling, Biedermann T, Földvári I, Ganser G, Girschick HJ, Hospach T, Huppertz HI, Keitzer R, Sexton RM, Michels H, D Moebius, Rogalski B, Thon A; Paediatric Rheumatology Collaborative Group. Ann Rheum Dis. 2004 Dec; 63 (12): 1638-44. Epub 2004 28 Apr Review.

Shingles – Herpes Zoster

Shingles – Herpes Zoster Erysipelas – erysipelas . . . Acute, rarely chronic relapsing (recurring) running, caused by streptococcal infection of the skin, mucosal selterner.  Synonym: Rose, erysipelas, Streptodermia cutanea lymphatica Cause: pathogens are beta-hemolytic group A streptococci, probably all subtypes. Incubation period (time between infection and outbreak): 1 to 3 days, gelengentlich hours Contagiousness (infectiousness): low Infection: lubricants and droplet infection, as a source come infected persons into consideration, but the infection requires local or general immune deficiency. The pathogen penetrates usually a skin lesion or a Gewebedefektw, ie at locations where continuity separations skin made. This may be a little scratch, an insect bite, Geschwürzbildung by venous disorders or lymphedema, scars etc .

. often found esp. In erysipelas of the lower limbs an athlete’s foot infection or deep cracks to strong cornea.  Frequency: as a result of the extended use of antibiotics significantly declined; even the early observed peak age in infants and the age group of 30- to 50-year-old patient is blurring, accurate figures on the current status was not available to me Symptoms: From anscheinendem Welfare emerge on fatigue, steeply rising fever, tenderness and pain in the affected area. There is often chills, localized skin swelling with initially sharply demarcated erythema and clearly warming to burning heat. The beginning of flaming redness proceeds with increasing time in a darkly red to bluish acting areal redness where the demarcation is blurred and has tongue-like extensions; later ‘pallor of the Centre. It often also cause swelling of the regional lymph nodes. Rare are vesicular progressions of acute erysipelas. In face, the redness is often shaped butterfly. pictured right (to zoom Double). 52-year-old patient, high fever, strong beinträchtigtes general health and pain in the left groin as an expression of regional lymph node inflammation, pinhead erosion of the left dorsum of unknown origin, 2 days after initiation of treatment with 1 , 2 million units a depot penicillin significant easing of tension feeling and fever freedom patient was concerned, despite better general condition due to the gloomy red discoloration. Diagnosis: The diagnosis can be made usually from the clinical picture.

The direct detection of pathogens would require skin samples from the edge of redness, making it uncommon. As an indirect proof of the steeply rising Antistreptolysin titer used. In addition, you will find non-specific parameters such as elevated white blood cell count, erythrocyte sedimentation rate increased significantly; alpha- and betaGlobuline are increased, gamma-globulins decreased, esp. when repeating (recurrent) erysipelas are alpha-1 and beta1 globulin and transferrin increased. Clinic: The clinical course may be best to the typical skin manifestations are dargestell and described sufficiently in symptoms. Complications: swelling of the epiglottis (glottis) at the transition to the oral mucosa, cellulitis or gangrene as local complications in immunocompromised weak people. The recurrent (relapsing) wound Rose leads at intervals repeatedly fever, pain and swelling. This affects which are mainly those with chronic skin damage (leg ulcers, stasis dermatitis cracked at Kramp wires or similar chronic lesions, athlete’s foot well. The Erysipelrezidiv leads more often than on initial presentation to a blockage of the lymph vessels and thus runs the risk of Elephatiasis.  Prognosis: The prognosis is generally good. Perilous erysipelas is occasionally in elderly or save weak people. In addition, the prognosis is always determined by the simultaneous existence of a serious underlying disease.  Therapy: drug of choice is still penicillin.

It is important that the penicillin treatment with sufficient Dosiserung least to obtain more than 10 days. Only with a penicillin allergy or signs of a non-response (ie a resistance) should be soft to macrolide antibiotics or cephalosporins. When recurrent erysipelas can help prevent complications of the heart valves or to avoid chronic lymphedema, a month-long treatment with benzathine penicillin (as Pendysin ®) are introduced (depot injection 1x monthly). In general, the treatment can be performed on an outpatient basis. Complicated courses should the clinic.  Prophylaxis: No known! The disease hinterläß no lasting immunity. Chronic skin defects should be treated professionally. For rapid detection of sequelae of streptococcal infection by allergic and hyperergic reactions, antibody or toxin effects (acute rheumatiches fever, acute glomerulonephritis) should be a follow-up three to four weeks after a streptococcal infection! Infection Protection: No beonderen measures; no insulation ill patients. Disqualification in children’s institutions, in healthcare facilities (surgical and obstetrical departments) and are in the food industry to recovery are recommended for people with streptococcal skin disorders. Differential diagnosis (differentiation from other diseases): erythema chronicum migrans – usually lighter than the erysipelas, barely general symptoms continue erysipelas – localized, burning-itching, almost always precedes injury in meat and fish processing (butcher, shop assistant (especially after tick bite. ) , cooks), mostly on the hands, very rare today, Erythrasma intertrigonosum – seat in the bar, no complaints; .

. . Also all skin diseases that are associated with planar redness (allergies, contact dermatitis, eczema of all kinds) – usually this lack fever, pain and severe impairment of the general condition. Created: 09. 08. 2009 / update: no / author: F. Wiegleb (fwiegleb@gmx. de)